Effects of Statins and Hormone Replacement Therapy in Coagulation Profile of Menopausal Women With Dyslipidemia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: estroprogestins, Statin.
- Who it may be relevant to
- Registry conditions: Menopausal Complaints, Hypercholerolemia, Coagulation Tests. Basic parameters: 45 years — 55 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Role of STAtins in Reversing Coagulation Profile Changes Induced by Hormone Replacement Therapy in Menopausal Women With Hypercholesterolemia: the STAR-HRT Study
Overview
The goal of this study is to understand whether statin therapy, a common lipid-lowering therapy, may improve the coagulation profile of menopausal women with hypercholesterolemia undergoing hormone replacement therapy with oral estroprogestin. It will also learn about the liver safety of the combination. The main questions will be: 1. does hormone replacement therapy affect the coagulation profile? 2. when we add statin therapy due to hypercholesterolemia not improving with lifestyle, does it reverse eventual changes of the coagulation profile occurred after initiation of hormone replacement therapy? 3. do the two therapies have an effect on overall inflammation of the organism? Participants will be asked to participate to the study before starting any therapy, if they need hormone relacement therapy due to symptoms, if they have a new onset of dyslipidemia and if they do not have contraindications to the therapies object of the study. The study is observational, thus it will not affect in any way the clinical care, which will follow only guidelines. During routine blood sample collection, additional aliquotes will be taken for the study at the recruitment, after 3 months of hormone replacement therapy and lifestyle changes, at the end of the study (after one year from the recruitment).
Interventions
- Drug estroprogestins
To be included in the study, patients must have menopausal symptoms requiring hormone replacement therapy without contraindications to it. All cohorts will undergo this therapy. - Drug Statin
After 3 months, patients not controlling hypercholesterolemia with lifestyle changes will be prescribed statin as per clinical routine practice. They will be part of the HRT+statin cohort.
Primary outcome measures
- HRT+Statin vs HRT only on the endogenous thrombin potential of the thrombin generation assay [Time frame: From 3 months to end of study (12 months)]
Secondary outcome measures (4)
- HRT+Statin vs HRT only on the nAPCsr after TGA [Time frame: From 3 months to end of study (12 months)]
- HRT+statins vs HRT only do not increase liver transaminases [Time frame: From 3 months to end of study (12 months)]
- HRT+statins vs HRT only on coagulation factors [Time frame: From 3 months to end of study (12 months)]
- HRT+statins vs HRT only on inflammatory markers [Time frame: From 3 months to end of study (12 months)]
Eligibility criteria
Inclusion criteria
- Women aged between 45 and 55
- Early postmenopausal period (within 5 years of the last menstrual cycle).
- Prescription of oral estrogen-progestin HRT for symptoms that require it according to current guidelines
- Low-moderate cardiovascular risk (SCORE2 calculation and assessment based on age)
- LDL levels above target according to the class of risk
Exclusion criteria
- Recent pregnancy (<1 year) or current breastfeeding
- Ongoing therapies that interfere with the study objectives: HRT or other estroprogestin therapy, lipid-lowering drugs, anticoagulants, or antiplatelet agents
- Current or previous venous or arterial thrombotic event
- Diagnosis of cancer for which treatment is ongoing or has been discontinued for less than 10 years
- Known hereditary thrombophilia
- Chronic inflammatory bowel disease
- Diabetes mellitus
- Body mass index (BMI) > 30 kg/m²
- Acute/chronic liver failure or abnormal liver enzymes (ALT or AST > 100 IU/L; GGT > 100 IU/L; alkaline phosphatase > 250 IU/L)
- Other known risk factors for VTE or contraindications to HRT
- Refusal to take HRT
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Italy · 1 center
- Santa Chiara Hospital - University Hospital of Pisa — Pisa
Identifiers
NCT: NCT07742488 · STAR_HRT