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Not yet recruiting NCT07741591

Impact of Perioperative Antibiotic Use on Surgical Scarring

— Observational Surgical Scar Postoperative Scar

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Perioperative Antibiotic Exposure.
Who it may be relevant to
Registry conditions: Surgical Scar, Postoperative Scar. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Perioperative Antibiotic Use and Its Impact on Postoperative Scarring: A Retrospective Study

Overview

This retrospective observational cohort study will evaluate whether perioperative antibiotic use is associated with long-term surgical scar outcomes. The study will include adult patients who underwent body surface surgery at Nanfang Hospital between January 1, 2005 and January 1, 2025 and have available surgical, medication, and scar-related clinical records. The study will not assign participants to any treatment. Researchers will review existing medical records, perioperative antibiotic exposure, surgical characteristics, complications, and scar assessments or photographs. Scar outcomes will be assessed using modified visual analogue scale scores, scar width, scar type, and scar-related complications.

Interventions

  • Other Perioperative Antibiotic Exposure
    Patterns of perioperative antibiotic use documented in existing medical records, including timing, indication, antibiotic type, duration, frequency, and route of administration. No antibiotic treatment will be assigned or provided by the study.

Primary outcome measures

  • Overall Scar Appearance Score Assessed Using a Modified Visual Analogue Scale [Time frame: Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam]
Secondary outcome measures (4)
  • Scar Color Score Assessed Using a Modified Visual Analogue Scale [Time frame: Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam]
  • Scar Texture Score Assessed Using a Modified Visual Analogue Scale [Time frame: Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam]
  • Scar Width [Time frame: Scar photographs were taken during postoperative clinical follow-up, with an overall range from 3 months to 20 years after surgery. Given the wide span, the assessments will be stratified and reported according to the actual time of photography, for exam]
  • Scar-Related Complications [Time frame: Postoperative days 0 to 30 (inclusive). The timing of each complication was determined from medical records.]

Eligibility criteria

Inclusion criteria

  • Age 18 years or older.
  • Underwent body surface surgery at Nanfang Hospital between January 1, 2005 and January 1, 2025, with a linear surgical incision scar.
  • Presented to the Department of Plastic Surgery at Nanfang Hospital for surgical scar-related care.
  • Had no medical encounter record at Nanfang Hospital from January 1, 2025 to the time of study screening.
  • Available clear surgical records and perioperative medication records.

Exclusion criteria

  • Known tendency for pathological scarring or scar constitution.
  • History of chronic skin disease in the surgical area, such as psoriasis or eczema.
  • Uncontrolled diabetes mellitus, malnutrition, hypoalbuminemia, or long-term use of immunosuppressive agents or glucocorticoids.
  • Target scar received any scar-specific treatment after surgery, such as laser therapy, radiotherapy, drug injection, or surgical revision.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

China · 1 center
  • Nanfang Hospital, Southern Medical University — Guangzhou

Identifiers

NCT: NCT07741591 · NFEC-2026-164 · MR-44-26-022534

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗