Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Hearing Disorders and Deafness. Basic parameters: 18 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
SEQUOIA : Cognitive Processing of Natural Sequences in Humans and Artificial Intelligence (AI)
Overview
The goal of this study is to identify electrical patterns in the cortex that enable the generation of predictions in natural auditory sequences such as speech and music. Between 500 and 700 participants in total (250 to 350 normally hearing participants (including 60 to 120 participants from West Africa and 60 to 120 participants from Western Europe) and 250 to 350 participants with hearing loss (no restrictions on origin)). Participants will listen to naturally recorded music and speech via headphones. They will be asked to rate these stimuli on a scale from 0 to 10 in terms of pleasure and comprehension, using a keyboard and mouse or voice input. Additionally, they will be required to sing or produce novel/improvised vocal responses using high-fidelity microphones. This entire procedure will be conducted under electroencephalography (EEG) to record neuronal responses throughout the process.
Primary outcome measures
- Correlation between neural recordings and IA models [Time frame: Day 1]
Secondary outcome measures (4)
- Compare predictions generated across different cultural contexts [Time frame: Day 1]
- Compare predictions for identical stimuli across repeated sessions to establish a link between processing and successful memorization/retention. [Time frame: From enrollement to visit 2 (10 days)]
- Compare predictions generated between hearing individuals and those with hearing impairments. [Time frame: Day 2]
- Correlate predictive measures with responses to autism symptom questionnaires across the various experiments. [Time frame: Day 1]
Eligibility criteria
Inclusion criteria
For hearing participants:
- Average pure-tone thresholds ≤ 20 dB HL
For participants with hearing loss:
- Average pure-tone thresholds > 20 dB HL
For participants of West African origin:
- Average pure-tone thresholds ≤ 20 dB HL
- Declare that both parents are of West African origin, either by their own birth or by the birth of both of their parents.
Exclusion criteria
- No known neurological or audiological disorders
- Participants under legal guardianship (tutelle, curatelle)
- Participants deprived of legal liberty by judicial or administrative decision
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07740070 · 2024-102 SEQUOIA · 2025-A00021-48