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Not yet recruiting NCT07739706

A Novel Smartphone Application for Helping Teens Stop Vaping, QuitQuest Vaping R01

No phase Interventional Tobacco-Related Carcinoma

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Smartphone Application-based Intervention, Smartphone Application-based Intervention, Survey Administration, Interview.
Who it may be relevant to
Registry conditions: Tobacco-Related Carcinoma. Basic parameters: 13 years — 17 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

QuitQuest: Full Scale Randomized Trial of a Novel Smartphone Application to Help Teens Stop Vaping (QuitQuest Vaping R01)

Overview

This clinical trial compares a novel smartphone application (app) called QuitQuest to the National Cancer Institute's (NCI's) SmokefreeTeenQuitVaping (SFTQV) app in helping teens stop vaping. Despite recent declines, data shows that 8.5% of middle school (grades 6-8) and 18.1% of high school (grades 9-12) students in the United States (US) used electronic nicotine delivery systems (ENDS; variously known as vaping, electronic \[e\]-cigarettes, e-cigs, mods, and tank systems that contain nicotine). Use of any tobacco product during adolescence increases risk for lifelong nicotine addiction. ENDS use, in particular, leads to severe asthma attacks, e-cigarette or vaping product use-associated lung injury (EVALI), exposure to multiple lung irritants, including volatile organic compounds, and lasting harm to adolescent brain development. Despite evidence of potential long-term harms from ENDS, to date there have been limited evidence-based therapeutic options for ENDS cessation for adolescents and young adults. Traditional methods for delivering adolescent ENDS cessation interventions (e.g., quitlines and clinics) have limited reach. QuitQuest utilizes Acceptance and Commitment Therapy (ACT), a psychological intervention that uses acceptance and mindfulness strategies, together with commitment and behavior change strategies, to increase psychological flexibility, reduce distress, and promote behavior change through mechanisms that include cultivating acceptance of internal experience and aligning behavior with personal values. The SFTQV program is based on the US Clinical Practice Guidelines, offering practical advice and support via an app delivery format. The QuitQuest app may work better than the SFTQV app in increasing vape quit rates among teens.

Detailed description

OUTLINE: Participants are randomized to 1 of 2 arms.

ARM I: Participants download and install the QuitQuest app for 12 months on study.

ARM II: Participants utilize the National Cancer Institute's (NCI's) SFTQV app for 12 months on study.

Interventions

  • Behavioral Smartphone Application-based Intervention
    Use QuitQuest app
  • Behavioral Smartphone Application-based Intervention
    Use SFTQV app
  • Other Survey Administration
    Ancillary studies
  • Other Interview
    Ancillary studies

Primary outcome measures

  • Self-reported 30-day point prevalence abstinence (PPA) from electronic nicotine delivery systems (ENDS) use [Time frame: At 6 months post-randomization]
Secondary outcome measures (5)
  • Self-reported 30-day PPA from ENDS use [Time frame: At 3 and 12 months post-randomization]
  • Self-reported 24-hour PPA from ENDS use [Time frame: At 3, 6, and 12 months post-randomization]
  • Self-reported 7-day PPA from ENDS use [Time frame: At 3, 6, and 12 months post-randomization]
  • Self-reported 30-day PPA from ENDS use [Time frame: At 3, 6, and 12 months post-randomization]
  • Biochemical verification of self-reported abstinence among participants who opt in at baseline and complete testing [Time frame: Up to 12 months post-randomization]

Eligibility criteria

Inclusion criteria

  • Age 13 to 17
  • Used ENDS at least weekly in the past 30 days
  • Wants to quit ENDS within the next 30 days
  • If concurrently using any other nicotine or tobacco products, wants to quit using them within the next 30 days
  • Interest in learning skills to quit ENDS
  • Willing to be randomly assigned to either condition
  • Resides in the United States (US) for the next 12 months
  • Has daily access to their own smartphone
  • Ability to download a smartphone app
  • Able to read in English
  • Not using other ENDS cessation interventions
  • Have not participated in our prior studies
  • No household or family member participating
  • Willingness to complete survey and biochemical assessments at 3, 6, and 12 months
  • Providing phone number(s), email, and mailing address

Exclusion criteria

  • Exclusion criteria are the reverse of the inclusion criteria

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Prevention

Study locations

United States · 1 center
  • Fred Hutch/University of Washington Cancer Consortium — Seattle

Identifiers

NCT: NCT07739706 · RG1126381 · NCI-2026-04135 · FHIRB0021244

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗