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Not yet recruiting NCT07729384

A Study of Strengthening Teen Brain Resilience Using Music During Cancer Treatment

No phase Interventional Childhood Hematopoietic and Lymphatic System Neoplasm Childhood Malignant Solid Neoplasm Hematopoietic and Lymphatic System Neoplasm Malignant Solid Neoplasm

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Interview, Music Therapy, Survey Administration.
Who it may be relevant to
Registry conditions: Childhood Hematopoietic and Lymphatic System Neoplasm, Childhood Malignant Solid Neoplasm, Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm. Basic parameters: 12 years — 17 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Strengthening Teen Brain Resilience Using Music (STRUM) During Cancer Treatment: A Pilot Feasibility Trial

Overview

This clinical trial tests the feasibility and acceptability of the Strengthening Teen Brain Resilience Using Music (STRUM) intervention to improve radiation induced cognitive decline for adolescents undergoing radiation therapy for cancer treatment. Adolescents treated with radiation therapy for cancer often experience persistent cognitive deficits and reduced brain resilience or the ability to preserve cognitive and emotional functioning despite stressors. Musical instrument training has been shown to enhance memory, academic skills, and emotional well-being in youth. Although guitars are often the most preferred instrument, ukuleles offer greater accessibility due to their simplicity, affordability, and suitability for younger users. The STRUM intervention consists of virtual active music therapy ukulele lessons, which may be a feasible and acceptable way to improve radiation induced cognitive decline for adolescents undergoing radiation therapy for cancer treatment.

Interventions

  • Other Interview
    Ancillary studies
  • Procedure Music Therapy
    Attend STRUM sessions
  • Other Survey Administration
    Ancillary studies

Primary outcome measures

  • Percentage of eligible participants who consent to participate in this study (feasibility) [Time frame: At time of enrollment]
  • Proportion of STRUM sessions completed (feasibility) [Time frame: Up to 10 weeks]
  • Average weekly practice minutes [Time frame: Up to 10 weeks]
  • Percentage of participants who complete ≥ 90% of the measures at each timepoint (feasibility) [Time frame: Baseline, week 6, week 12, week 20]
  • Acceptability of the Strengthening Teen Brain Resilience Using Music (STRUM) intervention [Time frame: Approximately 2 weeks following end of intervention (week 12)]
  • Participant perspective on meaningfulness of the STRUM intervention [Time frame: Approximately 2 weeks following end of intervention (week 12)]
  • Change in brain resilience [Time frame: Baseline, week 6, week 12, week 20]

Eligibility criteria

Inclusion criteria

  • Aged 12-17 years at the time of enrollment
  • Receiving initial radiation therapy (RT) for cancer treatment with curative intent at the Mayo Clinic Arizona
  • Able to provide assent
  • Able to read and write in English
  • Have access to an electronic device with videoconferencing capability

Exclusion criteria

  • Less than three-month prognosis
  • Past history of RT
  • Self-reported visual, hearing, or cognitive impairment impeding the ability to complete the STRUM intervention
  • Prior receipt of ukulele or guitar lessons
  • Actively receiving musical instrument lessons

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
N/A
Model
Single group
Masking
Open label
Primary purpose
Supportive care

Study locations

United States · 1 center
  • Mayo Clinic in Arizona — Scottsdale

Identifiers

NCT: NCT07729384 · 25-014110 · NCI-2026-03943

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗