Vascular Aging and Acute Kidney Injury After Cardiac Surgery
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Multidimensional Vascular Aging Assessment.
- Who it may be relevant to
- Registry conditions: Acute Kidney Injury Cardiac Surgery, Postoperative Complications, Vascular Aging. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Multidimensional Assessment of Vascular Aging and Its Association With Postoperative Acute Kidney Injury in Patients Undergoing Cardiac Surgery
Overview
This prospective observational cohort study will enroll adult patients undergoing cardiac surgery at Nanjing First Hospital, Nanjing Medical University. The study will evaluate multidimensional vascular aging markers before surgery and assess their association with postoperative acute kidney injury within 7 days after surgery. No intervention will be assigned by the study protocol, and all perioperative management will follow routine clinical practice.
Detailed description
Acute kidney injury is a common postoperative complication after cardiac surgery and is associated with adverse short-term and long-term outcomes. Vascular aging may reflect systemic vascular dysfunction, impaired vascular compliance, endothelial dysfunction, and reduced renal perfusion reserve, which may increase susceptibility to postoperative acute kidney injury.
This prospective observational cohort study will include adult patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University. Perioperative vascular aging-related indicators will be collected according to the study protocol. These indicators may include noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. Postoperative renal function will be monitored after surgery, and acute kidney injury will be assessed within 7 days after surgery according to predefined diagnostic criteria.
The primary objective is to investigate the association between multidimensional vascular aging markers and the occurrence and severity of postoperative acute kidney injury. Secondary analyses may evaluate the relationships between vascular aging burden and postoperative clinical outcomes, including intensive care unit stay, hospital stay, and other postoperative complications when available. This is an observational study, and no treatment, surgical procedure, or perioperative management strategy will be assigned by the study protocol.
Interventions
- Other Multidimensional Vascular Aging Assessment
Perioperative assessment of vascular aging-related indicators, including noninvasive vascular assessments, hemodynamic measurements, and relevant clinical and laboratory variables. The assessment is observational and will not determine the treatment, surgical procedure, or perioperative management assigned to participants.
Primary outcome measures
- Incidence of Postoperative Acute Kidney Injury Within 7 Days After Surgery [Time frame: From the date of surgery to postoperative day 7]
Secondary outcome measures (1)
- Severity of Postoperative Acute Kidney Injury [Time frame: From the date of surgery to postoperative day 7]
Eligibility criteria
Inclusion criteria
- Adult patients aged 18 years or older.
- Patients scheduled to undergo cardiac surgery at Nanjing First Hospital, Nanjing Medical University.
- Patients who are able to provide written informed consent.
- Patients who are expected to undergo perioperative vascular aging assessment and postoperative renal function monitoring according to the study protocol.
Exclusion criteria
- Patients younger than 18 years.
- Patients with preoperative end-stage renal disease or maintenance dialysis.
- Patients who are unable to complete the study-specified vascular aging assessment.
- Patients who decline participation or withdraw informed consent.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Nanjing First Hospital, Nanjing Medical University — Nanjing
Identifiers
NCT: NCT07727772 · KY20260625-09