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Not yet recruiting NCT07726498

STRIDE: Strength of The Calf Muscles and Their Role In Declining Effectiveness of Movement With Aging

— Observational Sarcopenia Aging Muscle Weakness or Atrophy Frailty

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: No intervention (observational study).
Who it may be relevant to
Registry conditions: Sarcopenia, Aging, Muscle Weakness or Atrophy, Frailty. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United Kingdom
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Overview

The calf muscles (plantarflexors) are the most important muscles for walking, running and daily activities. Weakness of these muscles through aging and disease significantly impact a person's ability to walk and complete daily activities. By assessing calf strength, it is possible to identify people at risk of falls, and a condition called sarcopenia (which means loss of muscle mass, strength and function). Unfortunately, most of the studies that have examined this have used specialist equipment unavailable to hospital staff. Our study aims to use commercially available equipment to explore the relationship between plantarflexor muscle strength and physical performance in adults living with or without sarcopenia, including those at risk of it. The study will determine if stronger/weaker calf muscles associated with sarcopenia influence the ability to walk and do things more easily. We will complete strength tests of the calf, thigh and hand, assess walking using a special camera system, use an ultrasound scan to look at the Achilles tendon, use a scan to look at how stiff your calf muscles are, assess your body composition, complete a physical performance test and some questionnaires. Each participant will complete the measures during one clinic visit

Detailed description

This study aims to assess the relationship between plantarflexor (calf muscles) muscle strength and physical performance between people with and without sarcopenia. The measurements include Isometric plantarflexor strength testing, Theia markerless motion capture system, Ultrasound Tissue Characterization Imaging, Elastography, Grip strength, Isometric Knee Extension Strength Test, Bioelectrical Impedance analysis, Short Physical Performance Battery. In addition the SARC-F, Falls Efficacy Scale- International (FES-I), EuroQol- 5 Dimension (EQ-5D-5L) and Short-Form-12-health-survey (SF-12) questionnaires will be completed.

Interventions

  • Other No intervention (observational study)
    No intervention (observational study)

Primary outcome measures

  • Isometric plantarflexor strength testing [Time frame: Baseline]
Secondary outcome measures (11)
  • Theia markerless motion capture system [Time frame: Baseline]
  • Ultrasound Tissue Characterization Imaging [Time frame: Baseline]
  • Elastography [Time frame: Baseline]
  • Grip strength [Time frame: Baseline]
  • Isometric Knee Extension Strength Test [Time frame: Baseline]
  • Bioelectrical Impedance analysis [Time frame: Baseline]
  • Short Physical Performance Battery [Time frame: Baseline]
  • SARC-F questionnaire [Time frame: Baseline]
  • Falls Efficacy Scale- International (FES-I) [Time frame: Baseline]
  • EuroQol- 5 Dimension (EQ-5D-5L) [Time frame: Baseline]
  • Short-Form-12-health-survey (SF-12) [Time frame: Baseline]

Eligibility criteria

Inclusion criteria

  • Participant is able and willing to provide informed consent to participate in the study
  • Aged 18 years or over
  • Ambulatory status: able to walk independently with or without aids
  • Able to attend clinic

Exclusion criteria

  • Participant is unwilling or unable to give informed consent.
  • Palliative/ end of life
  • Moderate to severe communication difficulties/ cognitive function
  • Immobile
  • Lower limb surgery within the last 6 months
  • Recent lower limb fracture
  • Unstable cardiopulmonary conditions
  • Severe impairments of vision or vestibular system
  • Lower limb corticosteroid injection within the last 6 months
  • No restriction on language

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Cohort

Study locations

United Kingdom · 1 center
  • University of Leicester — Leicester

Identifiers

NCT: NCT07726498 · 1117 · 367102

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗