AOSLO Imaging for the Study of Cellular Alterations in Retinal Neurodegeneration
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: MONA Imaging System.
- Who it may be relevant to
- Registry conditions: Glaucoma Associated With Other Ocular Disorders, Retina Disorder. Basic parameters: 10 years — 79 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Primary objective: \- Acquisition and analysis of images for non-medical purposes using the MONA IV system, an adaptive-optics-corrected scanning ophthalmoscope. Secondary objectives: * To measure the reproducibility of assessments; * To evaluate the detection of progressive changes.
Detailed description
Patients:
* 100 subjects aged 10 to 79 years with a condition that may affect the inner retina (e.g., glaucoma, optic neuropathy, etc.) * 100 subjects aged 10 to 80 years with a condition that may affect the outer retina (e.g., AMD, retinitis pigmentosa, etc.) * Male or female * Covered by health insurance
Healthy volunteers:
* 30 subjects aged over 50 and under 80 * 30 subjects aged over 18 and under 50 * Male or female * Healthy subjects with no known condition that directly or indirectly affects the structure of the eye * Covered by health insurance
For all subjects:
* Inability to remain motionless on a standard ophthalmic chin rest. RETION\_Protocol\_v2.0 dated June 10, 2026\_IDRCB: 2026-A00324-47 Page 10 of 44 * Subjects taking medications or suffering from a medical condition that could interfere with the evaluations planned under the protocol; * Participants allergic to tropicamide in cases where pupil dilation is required.
Interventions
- Device MONA Imaging System
acquisition mode with mona system
Primary outcome measures
- Proportion of images obtained with the MONA system deemed usable for the analysis of retinal microstructures. [Time frame: 48 months]
Eligibility criteria
Inclusion criteria
Patients:
- 100 subjects aged 10 to 79 years with a condition that may affect the inner retina (e.g., glaucoma, optic neuropathy, etc.)
- 100 subjects aged 10 to 80 years with a condition that may affect the outer retina (e.g., AMD, retinitis pigmentosa, etc.)
- Male or female
- Covered by health insurance
Healthy volunteers:
- 30 subjects aged over 50 and under 80
- 30 subjects aged over 18 and under 50
- Male or female
- Healthy subjects with no known condition that directly or indirectly affects the structure of the eye
- Covered by health insurance
Exclusion criteria
For all subjects:
- Inability to remain motionless on a standard ophthalmic chin rest. RETION\_Protocol\_v2.0 dated June 10, 2026\_IDRCB: 2026-A00324-47 Page 10 of 44
- Subjects taking medications or suffering from a medical condition that could interfere with the evaluations planned under the protocol;
- Participants allergic to tropicamide in cases where pupil dilation is required. ☞ Wearing glasses or contact lenses to correct a refractive error is not considered an exclusion criterion.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07725055 · P26-01