Analyses of Newly Diagnosed HIV Infection in Hong Kong
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: HIV -1 Infection. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Hong Kong
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Combined Epidemiologic and Molecular Network Analyses of Newly Diagnosed HIV Infection in Hong Kong
Overview
The goal of the project is to determine the epidemiologic status and changing patterns of HIV infection in Hong Kong. The main question it aims to answer is: \- what is the molecular pattern and burden of HIV-1 infections over the years
Detailed description
With the aim of determining the epidemiologic status and changing patterns of HIV infection in Hong Kong, a prospective cohort study is conducted with the objectives of: (a) describing the distribution of HIV-1 subtypes of newly diagnosed infection and their association with transmission routes; (b) characterising the transmission clusters of HIV infection and their dynamicity; and (c) evaluating the community burden of HIV and its changes over time. An epidemiologic cohort database would be established from newly diagnosed HIV infections reported in Hong Kong over a 4-year period. People living with HIV infections are invited to complete a self-administered questionnaire survey to capture data on their behavioural and network profiles prior to infection, supplemented by transcription of relevant clinical record data including CD4/CD8 and viral load measures. Blood sampling would be performed for supporting RNA sequencing. The main outcome measures are the prevalent and temporal changes of epidemiologic profile, molecular network patterns and population viral loads
Primary outcome measures
- main molecular HIV-1 subtype [Time frame: from enrollment to the end of the study at 4 years]
- main HIV transmission mode [Time frame: from enrollment to end of study at 4 years]
Secondary outcome measures (2)
- changes in HIV molecular pattern [Time frame: from enrolment to end of study at 4 years]
- Change in transmission mode [Time frame: from enrolment to end of study at 4 years]
Eligibility criteria
Inclusion criteria
- adult of age 18 or above, who are
- people living with HIV, and
- attending the service of an HIV specialist clinic in the public service in Hong Kong
Exclusion criteria
- travelers or visitors who are temporarily staying in Hong Kong
- prisoners
- patients with mental illnesses who are unable to make informed decision
- patients whose HIV diagnosis was made outside Hong Kong and whose treatment have already started.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Hong Kong · 1 center
- S.H. Ho Research Centre for Infectious Diseases — North Point
Identifiers
NCT: NCT07725042 · HK HIV newly diagnosed