Diagnostic Accuracy of ONSD, ODE, and the Crescent Sign
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Ultrasound assessment.
- Who it may be relevant to
- Registry conditions: Assessment of ONSD, ODE and the Crescent Sign Using POCUS. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Diagnostic Accuracy of ONSD, ODE, and the Crescent Sign on Ultrasound for Identifying Increased Intracranial Pressure: A Multicenter Study
Overview
Our aim was to determine the diagnostic accuracy of the ONSD, ODE, and crescent sign, as detected by POCUS, in identifying the clinical and radiological features of increased intracranial pressure.
Detailed description
All participants presenting to the ED with various symptoms and undergoing cranial CT or MRI for the diagnosis of cranial pathologies who do not meet the exclusion criteria will be included in the study. Informed consent will be obtained from all patients prior to the study. For participants included in the study, the presence of ONSD, ODE, and the crescent sign will be assessed using bedside ultrasound, and the diagnostic value of these findings will be evaluated. The bedside ultrasound will form part of the critical area examination in the emergency department; it will incur no cost to the institution and will be performed and assessed by an emergency medicine specialist and their assistant.
Interventions
- Diagnostic test Ultrasound assessment
Determination of optic nerve sheath diameter (ONSD), optic disc elevation (ODE) and the presence of the crescent sign using bedside ultrasound
Primary outcome measures
- Primary outcome [Time frame: An average of 8 months]
Eligibility criteria
Inclusion criteria
- All patients presenting at the ED with any symptoms, who have undergone a cranial CT or cranial MRI for the diagnosis of cranial pathologies, and who do not meet the exclusion criteria
Exclusion criteria
- Patients under the age of 18
- Patients who have not undergone a cranial CT or cranial MRI
- Patients with orbital injuries
- Patients in whom ultrasonographic measurements cannot be performed
- Patients brought to ED following a cardiac arrest
- Patients who do not consent to diagnosis and treatment of their own volition
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Turkey (Türkiye) · 1 center
- Recep Tayyip Erdoğan University Rize Training and Research Hospital — Rize
Publications
- Janitschke D, Stogbauer J, Lattanzi S, Brigo F, Lochner P. B-mode transorbital ultrasonography for the diagnosis of idiopathic intracranial hypertension: an updated systematic review and meta-analysis. Neurol Sci. 2023 Dec;44(12):4313-4322. doi: 10.1007/s10072-023-07016-z. Epub 2023 Aug 21. PMID 37599314
- Lunia V, Kappagantu V, Bhoi SK, Sinha TP, Jamshed N, Kumar A, Ekka M, Mishra PR, Pandey S. Diagnostic Accuracy of Crescent Sign by Ultrasound in Identifying Increased Intracranial Pressure. J Ultrasound Med. 2026 Jul;45(7):1477-1484. doi: 10.1002/jum.70192. Epub 2026 Feb 3. PMID 41631636
- Sahin A, Akilli NB, Koylu R. The test characteristics of ONSD and ODE tests in predicting the prognosis of patients with traumatic brain injury. Am J Emerg Med. 2026 May;103:170-175. doi: 10.1016/j.ajem.2026.02.015. Epub 2026 Feb 12. PMID 41720038
- Tessaro MO, Friedman N, Al-Sani F, Gauthey M, Maguire B, Davis A. Pediatric point-of-care ultrasound of optic disc elevation for increased intracranial pressure: A pilot study. Am J Emerg Med. 2021 Nov;49:18-23. doi: 10.1016/j.ajem.2021.05.051. Epub 2021 May 21. PMID 34051397
- Marmarou A, Anderson RL, Ward JD, et al. Impact of ICP instability and hypotension on outcome in patients with severe head trauma. J Neurosurg 1991; 75:S59-S66.
Identifiers
NCT: NCT07719842 · MuratYazıcı