Influence of Cataract Surgery on Corneal Biomechanical Properties in Patients With Pseudoexfoliation Syndrome
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Pseudoexfoliation Syndrome, Cataract. Basic parameters: 50 years — 85 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Croatia
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Influence of Cataract Surgery on Corneal Biomechanical Properties in Patients With Pseudoexfoliation Syndrome: A Prospective Observational Cohort Study
Overview
Pseudoexfoliation syndrome is associated with alterations in the biomechanical properties of the cornea. This prospective observational cohort study aims to evaluate changes in corneal biomechanical properties after standard phacoemulsification cataract surgery in patients with pseudoexfoliation syndrome compared with patients without pseudoexfoliation syndrome. Corneal hysteresis (CH) and corneal resistance factor (CRF) will be measured using the Ocular Response Analyzer before surgery and at postoperative day 1, day 7, and day 30. The study will enroll patients undergoing routine cataract surgery to compare postoperative changes in CH and CRF between the pseudoexfoliation and control groups.
Primary outcome measures
- Change in corneal hysteresis (CH) [Time frame: Baseline, postoperative day 1, day 7 and day 30]
Secondary outcome measures (1)
- Change in corneal resistance factor (CRF) [Time frame: Baseline, postoperative day 1, day 7 and day 30]
Eligibility criteria
Inclusion criteria
- adults aged 50 years and older
- presence of age-related cataract requiring phacoemulsification cataract surgery
- presence of pseudoexfoliation syndrome (PEX group) or absence of pseudoexfoliation syndrome (control group)
- ability and willingness to provide written consent
Exclusion criteria
- previous ocular surgery,
- corneal disease,
- glaucoma or ocular hypertension,
- dry eye disease (Schirmer test <10 mm, tear break-up time <5 seconds or positive fluorescein staining),
- high refractive error (myopia > -6.00 D or hyperopia > +5.00 D),
- unilateral pseudoexfoliation when the eye scheduled for surgery showed Adults no signs of PEX,
- intraoperative or postoperative complications,
- any ocular disease that could influence corneal biomechanics
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Croatia · 1 center
- Eye Clinic Medic Jukic — Split
Identifiers
NCT: NCT07719101 · PEX-CHCRF-2026