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Recruiting NCT07718347

Post-market Cosmetic Evaluation of Ariessence™ Pure PDGF+ Following Ablative Laser

No phase Interventional Immediate Post-Treatment Care Aging Mid-Face Aging

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: ariessence pure PDGF+™ is a sterile aqueous formulation containing Hyaluronic Acid and pure platelet-derived growth factor (PDGF)..
Who it may be relevant to
Registry conditions: Immediate Post-Treatment Care, Aging Mid-Face, Aging. Basic parameters: 40 years — 70 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

A Multi-center, Post-market Cosmetic Evaluation of Ariessence™ Pure PDGF+ Following Ablative Laser for the Tolerability and Improvement in the Appearance of Aging Skin.

Overview

ariessence is intended to be used as a viscous, leave-on solution designed for topical application to the face. It is intended to be used following non-medical cosmetic procedures, performed by licensed healthcare professionals to enhance comfort and maintain skin hydration. This study is designed to be a multi-center, post-market cosmetic evaluation of ariessence applied to the full face after an ablative laser procedure to evaluate improvements in procedure tolerability and improvements in the appearance of the skin, compared to an emollient control.

Detailed description

To compare procedure tolerability of the treated facial area between ariessence and standard aftercare (Aquaphor). Tolerability, using subject tolerability assessments (subject diaries), investigator tolerability assessments, and standardized day-3/7/14 photographs, with site confirmation.

Interventions

  • Other ariessence pure PDGF+™ is a sterile aqueous formulation containing Hyaluronic Acid and pure platelet-derived growth factor (PDGF).
    To compare time to appearance-based recovery and subject satisfaction between ariessence and standard of care groups using standardized photographs and investigator/subject ratings for tolerability and satisfaction

Primary outcome measures

  • Clinical Measures [Time frame: Baseline (Day 0) through Day 84 (End of Study).]
  • Patient-Reported Outcomes [Time frame: Baseline through day 84]
  • Photography [Time frame: Baseline through Day 84]
  • Investigator Objective Tolerability Assessment [Time frame: Baseline through Day 84]
  • Erythema grading (0-4 scale) [Time frame: Baseline through Day 84 (End of Study)]
  • Clinician's Global Aesthetic Improvement Scale (CGAIS). [Time frame: Baseline through Day 84 (End of STudy)]

Eligibility criteria

Inclusion criteria

-:Adults 40-65 70 years

  • Glogau III-IV
  • Fitzpatrick II-IV.
  • Suitable for ablative laser
  • non-smoker ≥ 3 years
  • Willing to comply with post-procedure regimen
  • patient reported outcome documentation, and photo documentation.

Exclusion criteria

  • Fitzpatrick I or > IV,
  • recent facial procedures (< 6 months)
  • active skin disease
  • pregnancy/lactation
  • implanted devices
  • history of keloids.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Triple blind
Primary purpose
Treatment

Study locations

United States · 2 centers
  • Laser & Skin Surgery Medical Group — Sacramento
  • The Practice of Brian S. Biesman, MD — Nashville

Publications

  • Sharma AN, Patel BC. Laser Fitzpatrick Skin Type Recommendations. In: StatPearls. StatPearls Publishing; 2025. Accessed October 28, 2025. http://www.ncbi.nlm.nih.gov/books/NBK557626/
  • Glogau RG. Aesthetic and anatomic analysis of the aging skin. Semin Cutan Med Surg. 1996 Sep;15(3):134-8. doi: 10.1016/s1085-5629(96)80003-4. PMID 8948530

Identifiers

NCT: NCT07718347 · LRM-ARS-PLF 401

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗