Association Between Pain Catastrophizing and PONV in Laparoscopic Cholecystectomy Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Vomiting, Postoperative, Pain, Nausea and Vomiting, Postoperative, Pain Catastrophizing. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Relationship Between Pain Catastrophizing Scale and Postoperative Nausea and Vomiting in Patients Undergoing Laparoscopic Cholecystectomy
Overview
This study aims to explore whether patients' tendency to exaggerate or focus on pain (pain catastrophizing) is related to experiencing nausea and vomiting after surgery. The study will include patients undergoing laparoscopic cholecystectomy. Before surgery, patients will answer questions measuring pain catastrophizing and rate their pain during intravenous cannulation. Nausea and vomiting will be assessed at various times during the first 24 hours after surgery. The results may help better understand how psychological factors affect postoperative symptoms.
Detailed description
This study is designed as a prospective, cross-sectional, and observational study. The Pain Catastrophizing Scale (PCS) is a well-established self-report instrument developed to assess catastrophic thinking related to pain. It evaluates how individuals perceive and respond to pain, focusing on tendencies such as rumination, magnification, and feelings of helplessness. Evidence suggests that PCS is a strong predictor of pain intensity, independent of anxiety levels. In this study, the validated Turkish version of the Pain Catastrophizing Scale will be used.
Postoperative nausea, vomiting, and retching are common adverse events that can complicate recovery from anesthesia. Patients often perceive these symptoms as more distressing than postoperative pain, and they represent important outcomes affecting patient satisfaction and recovery.
The present study aims to investigate the relationship between pain perception during intravenous (IV) cannulation, pain catastrophizing levels, and postoperative nausea and vomiting. By evaluating numeric pain scores during IV access alongside PCS scores, this study seeks to explore whether preoperative pain perception and psychological factors are associated with the frequency of postoperative nausea and vomiting.
The findings of this study are expected to contribute to a better understanding of the role of psychological factors in postoperative symptoms and may help improve anesthesia practices by supporting more individualized, patient-centered perioperative care.
Primary outcome measures
- Incidence of postoperative nausea and vomiting (PONV) [Time frame: Within 24 hours postoperatively]
Secondary outcome measures (1)
- Association between IV cannulation pain and pain catastrophizing [Time frame: Preoperative period]
Eligibility criteria
Inclusion criteria
- Adult patients aged 18-65 years
- American Society of Anesthesiologists (ASA) physical status I-II-III
- Scheduled for elective laparoscopic cholecystectomy
- Able to provide informed consent
Exclusion criteria
- Age <18 or >65 years
- Emergency surgery
- ASA physical status > III
- Pregnancy
- Chronic opioid use
- Known drug allergy
- Psychiatric disorders
- Neurological diseases (central or peripheral neuropathy)
- History of cerebrovascular disease (stroke)
- Chronic renal disease
- Chronic pulmonary disease
- Patients who refuse to participate
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Turkey (Türkiye) · 1 center
- Trabzon Kanuni Education and Research Hospital — Trabzon
Publications
- Macario A, Weinger M, Carney S, Kim A. Which clinical anesthesia outcomes are important to avoid? The perspective of patients. Anesth Analg. 1999 Sep;89(3):652-8. doi: 10.1097/00000539-199909000-00022. PMID 10475299
- Uğurlu M, Karakaş Uğurlu G, Erten Ş, Çayköylü A. Validity of Turkish form of Pain Catastrophizing Scale and modeling of the relationship between pain-related disability with pain intensity, cognitive, and emotional factors. Psychiatry and Clinical Psychopharmacology. 2017;27(2):189-196. doi:10.1080/24750573.2017.1322672
- Borna S, Ho OA, Gomez-Cabello CA, Haider SA, Genovese A, Prabha S, Haider CR, Felton CL, McLeod CJ, Bruce CJ, Carter RE, Forte AJ. Impact of Demographics and Psychological Factors on Three-Day Postoperative Pain Perception Following Hand Surgery. J Clin Med. 2024 Dec 25;14(1):37. doi: 10.3390/jcm14010037. PMID 39797119
Identifiers
NCT: NCT07712211 · 10496660-2026/25027