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Enrolling by invitation NCT07710859

Concentric vs Eccentric Exercise in Blood Flow Restriction Training

No phase Interventional Exercise

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: concentric group, eccentric group.
Who it may be relevant to
Registry conditions: Exercise. Basic parameters: 18 years — 35 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Official title

Comparison of the Effectiveness of Concentric and Eccentric Exercises in Blood Flow Restriction Training

Overview

This randomized controlled trial will investigate the effects of blood flow restriction (BFR) training combined with concentric or eccentric exercise on upper extremity reaction speed, muscle strength, and muscle oxygenation in healthy adults aged 18-35 years. A total of 34 participants will be randomly allocated to either a BFR combined with concentric exercise group (n=17) or a BFR combined with eccentric exercise group (n=17). Before the intervention, maximal muscle strength will be determined using a one-repetition maximum (1RM) test for the dominant elbow flexor muscles. Upper extremity reaction speed will be assessed using the Nelson Hand Reaction Test. Biceps brachii muscle strength will be measured with a digital dynamometer, and muscle oxygenation will be evaluated using a near-infrared spectroscopy (NIRS) device. All outcome measures will be obtained 72 hours before the intervention and repeated 72 hours after completion of the training program by the same investigator. The findings of this study will contribute to understanding whether concentric or eccentric exercise combined with BFR training provides greater improvements in upper extremity reaction speed, muscle strength, and muscle oxygenation in healthy individuals.

Interventions

  • Other concentric group
    Participants assigned to this group will perform blood flow restriction (BFR) training combined with concentric elbow flexion exercises using the dominant upper extremity. Training will be performed three times per week for four weeks (12 sessions). Exercises will be performed at 20-30% of one-repetition maximum (1RM) using a pneumatic cuff applied to the proximal upper arm. The cuff pressure will be set at 50% of the individual's arterial occlusion pressure. Each session will consist of four se
  • Other eccentric group
    Participants assigned to this group will perform blood flow restriction (BFR) training combined with eccentric elbow flexion exercises using the dominant upper extremity. Training will be performed three times per week for four weeks (12 sessions). Exercises will be performed at 20-30% of one-repetition maximum (1RM) using a pneumatic cuff applied to the proximal upper arm. The cuff pressure will be set at 50% of the individual's arterial occlusion pressure. Each session will consist of four set

Primary outcome measures

  • Upper Extremity Reaction Time [Time frame: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.]
  • Biceps Brachii Muscle Strength [Time frame: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.]
  • Hand Grip Strength [Time frame: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.]
  • Pinch Strength [Time frame: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.]
  • One-Repetition Maximum [Time frame: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.]
  • Muscle Oxygen Saturation [Time frame: Baseline (72 hours before the intervention) and 72 hours after completion of the 4-week intervention.]

Eligibility criteria

Inclusion criteria

  • Being between 18 and 35 years of age
  • Physically inactive or minimally active individuals (International Physical Activity Questionnaire-Short Form. IPAQ-CF, <3000 MET-min/week)

Exclusion criteria

  • Having a history of musculoskeletal surgery within the last 6 months
  • Individuals with a history of orthopedic surgery within the last 6 months
  • Having high systolic blood pressure (≥140 mmHg)
  • Having a current history of cardiovascular disease
  • Participants who did not volunteer to participate in the study and did not provide informed consent were excluded from the study.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Other

Study locations

Turkey (Türkiye) · 1 center
  • Karabuk university — Karabük

Publications

  • Yasuda T, Loenneke JP, Thiebaud RS, Abe T. Effects of detraining after blood flow-restricted low-intensity concentric or eccentric training on muscle size and strength. J Physiol Sci. 2015 Jan;65(1):139-44. doi: 10.1007/s12576-014-0345-4. Epub 2014 Nov 8. PMID 25381173

Identifiers

NCT: NCT07710859 · blood flow restriction

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗