BIOANCIENT: Cohort of Centenarians in Navarra (1926-1927)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Aging, Cellular Senescence, Biomarkers / Blood, Age-Related Diseases. Basic parameters: from 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Spain
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Demographic aging is a growing global challenge, driven by increasing life expectancy and declining birth rates, with projections indicating that more than 30% of the European population will be over 65 years old by 2100. Centenarians represent a unique biological model of extreme longevity, often exhibiting delayed onset of age-related diseases and preserved functional capacity. This study aims to establish an intergenerational cohort of centenarians in Navarra (Spain) to investigate the biological, clinical, environmental, and lifestyle factors associated with extreme longevity. By integrating multidimensional data-including clinical assessments, functional and cognitive measures, and biological markers-this study seeks to improve understanding of aging mechanisms and identify potential determinants of healthy aging.
Detailed description
Demographic aging is a phenomenon with increasing structural impact, driven by rising life expectancy and declining birth rates. According to projections by Eurostat and the WHO, by 2050 more than 30% of the European population will be over 65 years old, posing significant challenges for the sustainability of healthcare and social systems, and requiring the development of specific strategies that integrate knowledge from geroscience, biotechnology, and artificial intelligence applied to health.
Navarre has privileged conditions for research into healthy aging, given its high rate of centenarians (44.09 per 100,000 inhabitants) and its high-level healthcare and scientific infrastructure. These strengths make the region an ideal environment for designing and implementing innovative strategies aimed at improving the health and quality of life of older adults, contributing to the sustainability of the healthcare system.
Centenarians constitute a particularly valuable biological model, as they reach advanced ages with relatively preserved functionality, suggesting the presence of protective mechanisms that remain incompletely understood. Contemporary geroscience adopts a holistic approach, emphasizing the interaction between genetic factors (such as longevity-associated alleles), epigenetic mechanisms (including DNA methylation), and environmental influences (including diet, physical activity, and living conditions) in shaping aging trajectories.
Multifactorial approaches have been increasingly applied to the study of centenarian cohorts, integrating clinical data with biomarkers of aging. Studies such as the Okinawa Centenarian Study have demonstrated associations between longevity and lifestyle factors including diet, physical activity, and social support, whereas the New England Centenarian Study has highlighted the contribution of genetic factors to extreme longevity and delayed onset of cardiovascular disease. European cohorts have similarly identified favorable metabolic profiles and delayed development of chronic conditions, often with a relevant hereditary component.
The present study aims to integrate multiple domains of knowledge in order to deepen the understanding of the biological mechanisms underlying longevity, reduce diagnostic barriers, optimize therapeutic strategies and healthcare resource utilization, and ultimately improve the quality of life of older adults.
Primary outcome measures
- Integrated biological aging profile based on clinical and multi-omics biomarkers. [Time frame: Baseline and 1-year follow-up]
Secondary outcome measures (12)
- Cognitive Function assessed with Mini Mental State Examination (MMSE) [Time frame: Baseline and 1-year follow-up]
- Functional status measured with Barthel Index [Time frame: Baseline and 1-year follow-up]
- Physical function assessed by Short Physical Performance Battery (SPPB) [Time frame: Baseline and 1-year follow-up]
- Frailty assessed by Fried Frailty Phenotype [Time frame: Baseline and 1-year follow-up]
- Lawton Instrumental Activities of Daily Living (IADL) [Time frame: Baseline and 1-year follow-up]
- Nutritional Status assessed using the Mini Nutritional Assessment - Short Form (MNA-SF) [Time frame: Baseline and 1-year follow-up]
- Hand Grip Strength [Time frame: Baseline and 1-year follow-up]
- Lower Limb Muscle Strength [Time frame: Baseline and 1-year follow-up]
- Sarcopenia Risk (SARC-F questionnaire) [Time frame: Baseline and 1-year follow-up]
- Cognitive Function (Clock Drawing Test) [Time frame: Baseline and 1-year follow-up]
- Depressive Symptoms (Geriatric Depression Scale - GDS-15) [Time frame: Baseline and 1-year follow-up]
- Health-Related Quality of Life (EQ-5D-5L) [Time frame: Baseline and 1-year follow-up]
Eligibility criteria
Inclusion criteria
- Individuals aged ≥100 years
- Residents of Navarre, Spain
Exclusion criteria
- Clinical decompensation within the last month, including hemodynamic instability, acute illness, or hospitalization;
- End-of-life condition, defined as a clinical state of irreversible deterioration with a life expectancy of days to weeks, as determined by a physician.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Spain · 1 center
- Navarrabiomed — Pamplona
Identifiers
NCT: NCT07707297 · BIOANCIENT