Effect Of Whole or Skimmed Milk Greek Yogurt on Integrated Muscle Protein Synthesis, Glucose Homeostasis, and Cognition in Post-Menopausal Women
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Skimmed vs Whole Milk Greek Yogurt.
- Who it may be relevant to
- Registry conditions: Obesity & Overweight, Women, Menopause. Basic parameters: 50 years — 65 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effect Of Whole or Skimmed Milk Greek Yogurt on Integrated Muscle Protein Synthesis, Glucose Homeostasis, And Cognition in Post-Menopausal Women
Overview
The study will examine the impact of adding two servings per day of skimmed or whole milk Greek yogurt on integrated muscle protein synthesis (iMPS), blood sugar control, and cognition in post-menopausal women with overweight and obesity.
Interventions
- Other Skimmed vs Whole Milk Greek Yogurt
Participants will be randomized to receive a standardized diet with either skimmed milk or whole milk Greek yogurt.
Primary outcome measures
- Integrated Muscle Protein Synthesis (iMPS) [Time frame: 1 week]
Secondary outcome measures (1)
- Glucose Homeostasis [Time frame: 1 week]
Eligibility criteria
Inclusion criteria
- Aged 50 to 65 years
- Body mass index ≥25 to <40 kg/m2 or body fat ≥36%
- Able to provide informed consent
- Absence of menstruation for ≥12 months without the use of hormonal contraceptives, or one of the following:
- Another medical cause of menopause e.g., history of bilateral oophorectomy
- Clinician-confirmed menopausal status for those with hysterectomy and retained/unknown ovaries
- Partial/total hysterectomy ≥12 months ago and current age ≥55 years
Exclusion criteria
- Allergy or intolerance to dairy products (other allergies or intolerances may be excluded if they are not compatible with the study meals and how they are prepared)
- Conditions, medications, or recent changes in medications that cause participants to be metabolically unstable (e.g., renal, cardiovascular, thyroid, polycystic ovary syndrome, type-1 and type-2 diabetes)
- Gastric bypass/bariatric surgery in the previous 5 years
- Pregnancy or nursing in the prior 12 months
- Weight loss or gain >5 kg in the last two months
- Unable or unwilling to suspend use of blood thinning medications and non-steroidal anti-inflammatory drugs for the duration of the study
- Unwilling to abstain from vigorous exercise for the study period
- Does not or will not eat all foods on the standardized diet (e.g., allergies, intolerances, or taste preferences)
- Participants may be excluded at the Principal Investigator's discretion if their health or body composition is not compatible with the required study procedures
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 1 center
- University of Arkansas for Medical Sciences — Little Rock
Identifiers
NCT: NCT07705724 · 300136