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Not yet recruiting NCT07705646

Comparison of Different Ventilation Modes for Reducing Kidney Motion During Retrograde Intrarenal Surgery

No phase Interventional Kidney Stones Nephrolithiasis

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Standard Ventilation, Hypoventilation, Intermittent Apnea Ventilation, One-Lung Ventilation.
Who it may be relevant to
Registry conditions: Kidney Stones, Nephrolithiasis. Basic parameters: 18 years — 75 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Turkey (Türkiye)
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Comparison of Different Ventilation Modes for Reducing Kidney Motion During Retrograde Intrarenal Surgery: A Prospective Randomized Controlled Trial

Overview

This randomized clinical trial will compare four ventilation strategies during retrograde intrarenal surgery performed under general anesthesia. The study aims to determine whether reducing respiratory-related kidney movement improves surgical success and decreases perioperative complications. Eighty adult patients will be randomly assigned to standard ventilation, hypoventilation, intermittent apnea ventilation, or one-lung ventilation. Surgical outcomes and perioperative complications will be compared between groups.

Detailed description

Retrograde intrarenal surgery is commonly performed under general anesthesia, but respiratory movement may interfere with kidney stability during the procedure. This prospective, randomized, single-center trial will compare standard ventilation, hypoventilation, intermittent apnea ventilation, and one-lung ventilation in adult patients undergoing retrograde intrarenal surgery. The primary objective is to determine whether different ventilation strategies improve surgical success by reducing kidney movement. Secondary outcomes include operative time, stone access time, fluoroscopy time, laser use time, complications, length of hospital stay, and postoperative stone-free rate.

Interventions

  • Procedure Standard Ventilation
    Volume-controlled mechanical ventilation using standard ventilator settings during general anesthesia.
  • Procedure Hypoventilation
    Volume-controlled mechanical ventilation using reduced tidal volume and respiratory rate during general anesthesia.
  • Procedure Intermittent Apnea Ventilation
    Intermittent apnea periods applied during selected stages of retrograde intrarenal surgery to reduce kidney motion.
  • Procedure One-Lung Ventilation
    One-lung ventilation applied during selected stages of retrograde intrarenal surgery to reduce kidney motion.

Primary outcome measures

  • Kidney Motion During Retrograde Intrarenal Surgery [Time frame: During surgery]
Secondary outcome measures (6)
  • Stone-free Rate [Time frame: Postoperative Day 30]
  • Operative Time [Time frame: During surgery]
  • Fluoroscopy Time [Time frame: During surgery]
  • Laser Activation Time [Time frame: During surgery]
  • Perioperative Complications [Time frame: Periprocedural]
  • Length of Hospital Stay [Time frame: Periprocedural]

Eligibility criteria

Inclusion criteria

Age 18-75 years. ASA physical status I-III. Scheduled for elective RIRS/RIRC under general anesthesia. No obstructive or restrictive pulmonary disease. No history of pneumothorax. No pulmonary mass or other significant respiratory disease. Normal coagulation parameters and not receiving antithrombotic therapy. No active urinary tract infection. Written informed consent.

Exclusion criteria

Age <18 or >75 years. ASA IV. Obstructive or restrictive pulmonary disease. History of pneumothorax. Pulmonary mass or significant respiratory disease. Receiving antithrombotic therapy or abnormal coagulation. Active urinary tract infection or urinary tract anatomical abnormality. Refusal or inability to provide informed consent.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Treatment

Study locations

Turkey (Türkiye) · 1 center
  • Sultan Abdulhamid Han Training and Research Hospital — Istanbul

Identifiers

NCT: NCT07705646 · 21-64

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗