Not yet recruiting NCT07701603
Effects of Blood Gas Perturbations
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Gas perturbation.
- Who it may be relevant to
- Registry conditions: Healthy. Basic parameters: 18 years — 55 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Effects of Blood Gas Perturbations on Neuromuscular Function of the Diaphragm and Lower Limbs at Rest and During Exercise.
Overview
In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.
Interventions
- Other Gas perturbation
Participants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition.
Primary outcome measures
- Diaphragm contractility [Time frame: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec]
Eligibility criteria
Inclusion criteria
- healthy
- non.smoking
- normal lung function
- BMI: 18.5-29.9 kg/m2
- willing to adhere to study rules
Exclusion criteria
- Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
- Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep
- Any metal or electronics inside of the body
- Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators
- History of seizures or epilepsy
- Tattoos on the stimulation sites
- Previous enrolment in this study
- For women: Pregnancy, breastfeeding, or intention to become pregnant during the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07701603 · REMEX-WP3