Not yet recruiting NCT07698314
A Pilot Study Assessing Myokines During an EXErcise Regimen After Treatment for Breast Cancer
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Conditioning Resistance Training, Strength Resistance Training, Hypertrophy Resistance Training.
- Who it may be relevant to
- Registry conditions: Cancer, Breast Cancer. Basic parameters: 20 years — 89 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Myo-EXERTBC: A Pilot Study Assessing Myokines During an EXErcise Regimen After Treatment for Breast Cancer
Overview
In this pilot study, the investigators will assess the changes in myokine production based on several different exercise regimens.
Interventions
- Behavioral Conditioning Resistance Training
Participants in this group will perform a conditioning regimen from the EXERT-BCHC protocol, specifically described as "double training". - Behavioral Strength Resistance Training
Participants in this group will perform a strength regimen from the EXERT-BCHC protocol, specifically described as "8x8". - Behavioral Hypertrophy Resistance Training
Participants in this group will perform a hypertrophy regimen from the EXERT-BCHC protocol, specifically described as the "control arm".
Primary outcome measures
- Change in Myokine Production After First Exercise Session [Time frame: Immediately before and immediately after the first exercise session.]
- Change in Myokine Production After Final Exercise Session of Each Week [Time frame: Immediately before and immediately after the final exercise session of weeks 1, 2, 3, and 4.]
- Change in Myokine Production After Final Exercise Session of the Month (End of Study) [Time frame: Immediately before and immediately after the final exercise session of week 4 (end of the 4-week exercise regimen).]
Eligibility criteria
Inclusion criteria
- Age 20-89 years
- Women prescribed exercise as a SOC
- Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast
- Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.
- Women with > 3 months of resistance training experience under expert guidance at the Allegheny Health Network Exercise Oncology Center
Exclusion criteria
- Any current treatment with cytotoxic chemotherapy for breast cancer
- Inability to safely engage in group sessions of resistance training as deemed by study PI
- Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by PI to be unsafe to engage in resistance training
- Pregnant women
- Males
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Other
Study locations
United States · 1 center
- AHN Allegheny General Hospital — Pittsburgh
Identifiers
NCT: NCT07698314 · 2026-125