Oral Microbiota and Muscle Function in the Ageing Subject
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Salivary and fecal microbiota sampling and muscle strength assessment.
- Who it may be relevant to
- Registry conditions: Non-hospitalised Men and Women Over 70 Years of Age. Basic parameters: from 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Oral Microbiota and Muscle Function in the Ageing Subject: MYOBIOTA Study
Overview
Ageing of the general population may be a risk factor for various complications, including sarcopenia. Sarcopenia is a progressive loss of muscle mass and muscle strength, leading to a decrease in functional capacities. It affects between 0.7% and 16% of European adults over 70 years of age (1). Recent studies suggest that the faecal microbiota may be altered with ageing but also according to sarcopenic status. Furthermore, no study has currently published data on the relationship between salivary microbiota and sarcopenic status. The main hypothesis of this study is that a decrease in salivary microbiota richness could be associated with impaired handgrip strength in the ageing subject.
Interventions
- Procedure Salivary and fecal microbiota sampling and muscle strength assessment
Collection of saliva and stool samples for microbiota analysis and assessment of handgrip strength in adults aged over 70 years.
Primary outcome measures
- Salivary microbiota richness [Time frame: baseline]
Secondary outcome measures (6)
- Fecal microbiota diversity [Time frame: 15 days]
- Title: Fecal microbiota richness [Time frame: 15 days]
- Salivary microbiota diversity [Time frame: 15 days]
- Fecal microbiota richness according to sarcopenia status [Time frame: 15 days]
- handgrip strength [Time frame: 15 days]
- Risk factors associated with low microbiota genomic diversity [Time frame: 15 days]
Eligibility criteria
Inclusion criteria
- Male or female adult volunteer, over 70 years of age
- Non-hospitalised
- Having read and understood the information letter and signed the consent form
- Affiliated with a Social Security scheme
Exclusion criteria
- Already included in an interventional drug clinical trial
- Unable to understand and complete the questionnaires
- Deprived of liberty by an administrative or judicial decision or protected adult subject (under guardianship, curatorship or judicial protection order)
- Receiving antibiotic treatment or having received antibiotic treatment during the previous 3 months
- Taking or having taken probiotics during the previous 3 months
- Having undergone colonic lavage/bowel cleansing during the previous 3 months
- Presenting one of the following situations likely to alter the microbiota: active cancer, eating disorders, exclusive vegetarian diet, history of digestive surgery
- Having a cardiac pacemaker
- Living in a nursing home for dependent elderly persons (EHPAD)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
France · 1 center
- Rouen University Hospital — Rouen
Identifiers
NCT: NCT07687511 · 2024/0100/HP · 2025-A02657-42