Transcranial Magnetic Stimulation in Laryngeal Dystonia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Active rTMS, Sham rTMS, Speech-Language Therapy.
- Who it may be relevant to
- Registry conditions: Laryngeal Dystonia, Spasmodic Dysphonia. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This randomized clinical trial with a crossover design aims to investigate the effects of neuromodulation through repetitive transcranial magnetic stimulation (rTMS) applied to patients diagnosed with laryngeal dystonia. Participants will undergo three experimental conditions: (1) rTMS alone, (2) rTMS combined with speech-language therapy, and (3) sham rTMS combined with speech-language therapy. The order of the conditions will be randomized. Each phase of the protocol will consist of five consecutive sessions. Outcomes will include acoustic vocal quality parameters, perceptual-auditory voice assessment, self-ratings of vocal effort, smoothed cepstral peak prominence measures, and global perceived change following the intervention. It is expected that the study will contribute to a better understanding of the effects of the intervention on vocal outcomes, supporting the optimization and standardization of therapeutic protocols for laryngeal dystonia.
Interventions
- Device Active rTMS
Active repetitive transcranial magnetic stimulation (rTMS) delivered using a magnetic stimulator according to the study protocol. - Device Sham rTMS
Sham repetitive transcranial magnetic stimulation (rTMS) delivered using a sham stimulation procedure designed to mimic active rTMS without delivering therapeutic magnetic stimulation. - Device Speech-Language Therapy
Standardized speech-language therapy focused on voice rehabilitation delivered by a licensed speech-language pathologist according to the study protocol.
Primary outcome measures
- Acoustic Voice Parameters Assessed Using VoxMetria® and FonoView® Software [Time frame: through study completion, an average of 6 months]
Secondary outcome measures (3)
- Vocal Effort Assessed by the Borg Category Ratio 10 Scale for Vocal Effort [Time frame: through study completion, an average of 6 months]
- Patient Global Impression of Change Assessed by the Patient Global Impression of Change Scale [Time frame: through study completion, an average of 6 months]
- Voice-Related Quality of Life Assessed by the Voice-Related Quality of Life Questionnaire (Brazilian Portuguese Version - QVV) [Time frame: through study completion, an average of 6 months]
Eligibility criteria
Inclusion criteria
- Adults (≥18 years) of any sex with a confirmed diagnosis of laryngeal dystonia
- Participants not undergoing botulinum toxin treatment at the time of the intervention
- Ability to provide informed consent
- Ability to complete all study assessments and intervention procedures
Exclusion criteria
- Other forms of dystonia
- Vocal fold lesions
- Vocal fold paralysis
- Contraindications to repetitive transcranial magnetic stimulation (rTMS)
- Inability to complete study assessments or intervention procedures
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Triple blind
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07683767 · rTMS_Laryngeal_Dystonia