Pharmacokinetics of Petrelintide in Participants With Impaired Hepatic Function
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Petrelintide.
- Who it may be relevant to
- Registry conditions: Impaired Hepatic Function. Basic parameters: 18 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Poland, Slovakia
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Pharmacokinetics of Petrelintide Following Administration to Participants With Impaired Hepatic Function
Overview
This clinical research trial is testing the investigational medicinal product (IMP) petrelintide that is being developed for body weight reduction in people living with obesity or overweight who have comorbidities. The aim of this clinical research trial is to investigate whether the pharmacokinetics (PK) of petrelintide will be different in people with hepatic impairment (HI) compared to people with normal hepatic function.
Detailed description
This is a Phase 1, open-label, multicenter, single-dose, parallel-group, non-randomized trial to evaluate the PK, safety, and tolerability of petrelintide after a single dose in participants with mild, moderate, or severe HI, and participants with normal hepatic function. Allocation of participants to the hepatic function groups will be based on Child-Pugh classification.
Each participant will receive a single subcutaneous (SC) dose of petrelintide on Day 1.
Up to 18 participants with normal hepatic function and 18 participants with HI (6 participants each in the following groups: mild, moderate, or severe HI) will participate in this trial.
Interventions
- Drug Petrelintide
Petrelintide will be administered as a single SC injection.
Primary outcome measures
- Area Under the Plasma Concentration-time Curve (AUC) from Time Zero to Infinity (AUC0-inf) of Petrelintide [Time frame: Day 1 (pre-dose) to Day 50 (Follow-up)]
Secondary outcome measures (7)
- AUC from Time Zero up to Time of Last Measurable Concentration (AUC0-last) of Petrelintide [Time frame: Day 1 (pre-dose) to Day 50 (Follow-up)]
- Maximum Observed Plasma Concentration (Cmax) of Petrelintide [Time frame: Day 1 (pre-dose) to Day 50 (Follow-up)]
- Time to Cmax (tmax) [Time frame: Day 1 (pre-dose) to Day 50 (Follow-up)]
- Apparent Clearance (CL/F) of Petrelintide [Time frame: Day 1 (pre-dose) to Day 50 (Follow-up)]
- Terminal Elimination Half-life (t1/2) of Petrelintide [Time frame: Day 1 (pre-dose) to Day 50 (Follow-up)]
- Apparent Volume of Distribution at Terminal Phase (Vz/F) of Petrelintide [Time frame: Day 1 (pre-dose) to Day 50 (Follow-up)]
- Number of Participants Experiencing Treatment-emergent Adverse Events (TEAEs) [Time frame: Day 1 up to Day 50]
Eligibility criteria
Inclusion criteria
All participants:
- Sex: male and female participants.
- Body mass index (BMI): 18.5 to 40.0 kg/m\^2, inclusive, at screening.
Additional Inclusion Criteria for Participants with Normal Hepatic Function
- Participants who are considered healthy as determined by medical history, physical examination, and other screening procedures, with clinically normal hepatic function at screening..
- Clinical laboratory test results within normal reference range for the population, or results with acceptable deviations that are judged not to be clinically significant by the Investigator.
Additional Inclusion Criteria for Participants with Hepatic Impairment
- Participants with stable HI for at least 3 months, classified as Child-Pugh Grade A, B, or C as assessed by the Investigator.
- Participants should be otherwise judged to be in acceptable health (type 2 diabetes mellitus \[T2DM\] is allowed) in the opinion of the Investigator based on a medical evaluation (including a physical examination, medical history, electrocardiogram \[ECG\], vital signs, concomitant medication and the results of laboratory safety tests) performed during the screening visit.
- Participants with T2DM may be enrolled if they have/are: a. Hemoglobin A1c ≤11% at screening b. On a stable regimen for at least 8 weeks prior to screening, defined as: stable diet and exercise program, and/or, stable dose of metformin, and/or, stable dose of a sodium-glucose cotransporter-2 inhibitor.
Exclusion criteria
All participants:
- Known or suspected hypersensitivity to the IMP or related products.
- Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using a highly effective contraceptive method.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Slovakia · 2 centers
- Summit Clinical Research s.r.o. — Bratislava
- Summit Clinical Research s.r.o. — Malacky
Poland · 1 center
- Centrum Badan Klinicznych Piotr Napora Lekarze sp.p. — Wroclaw
Identifiers
NCT: NCT07682818 · ZP8396-25077 · 2025-523641-10-00 · Universal Trial number