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Recruiting NCT07672210

PregnAncy-Related Aortic DISsEction in China

— Observational Pregnancy Complication Aortic Dissection Marfan Syndrome Loeys-Dietz Syndrome

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Intervention strategies including medication or surgery.
Who it may be relevant to
Registry conditions: Pregnancy Complication, Aortic Dissection, Marfan Syndrome, Loeys-Dietz Syndrome. Basic parameters: 16 years — 55 years · Female.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

PregnAncy-Related Aortic DISsEction in China: A Multicenter National Registry

Overview

A multicenter observational study on pregnancy-related aortic dissection

Interventions

  • Other Intervention strategies including medication or surgery
    Medication or surgery (delivery or surgery first, or single-stage delivery and surgery) is determined based on gestational age and the type of AD, and also in consideration of the decisions made by the patient and their relatives.

Primary outcome measures

  • Early-term mortality of mothers and fetuses (or newborns) [Time frame: Death within 30 days after treatment.]
  • Long-term mortality of mothers and children [Time frame: Through study completion, an average of 3 years.]
Secondary outcome measures (2)
  • The incidence of maternal adverse events [Time frame: Through study completion, an average of 3 years.]
  • The incidence of neonatal developmental abnormalities [Time frame: Through study completion, an average of 3 years.]

Eligibility criteria

Inclusion criteria

  • Aortic dissection is diagnosed based on symptoms and physical findings, and confirmed by computed tomographic angiography (CTA) and/or transthoracic echocardiography
  • Aortic dissection occurring during pregnancy or within 12 weeks postpartum

Exclusion criteria

  • Previous history of aortic dissection, but no new aortic dissection occurring during pregnancy or within 12 weeks postpartum

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

China · 4 centers
  • DeltaHealth Hospital Shanghai — Shanghai
  • Beijing Anzhen Hospital — Beijing
  • Guangdong Provincial Hospital — Guangzhou
  • Wuhan Union Hospital — Wuhan

Publications

  • Zhu JM, Ma WG, Peterss S, Wang LF, Qiao ZY, Ziganshin BA, Zheng J, Liu YM, Elefteriades JA, Sun LZ. Aortic Dissection in Pregnancy: Management Strategy and Outcomes. Ann Thorac Surg. 2017 Apr;103(4):1199-1206. doi: 10.1016/j.athoracsur.2016.08.089. Epub 2016 Nov 5. PMID 27825688
  • Ma WG, Zhu JM, Chen Y, Qiao ZY, Ge YP, Li CN, Zheng J, Liu YM, Sun LZ. Aortic dissection during pregnancy and postpartum in patients with Marfan syndrome: a 21-year clinical experience in 30 patients. Eur J Cardiothorac Surg. 2020 Aug 1;58(2):294-301. doi: 10.1093/ejcts/ezaa048. PMID 32259204
  • Zhu JM, Chen SW, Ma WG, Chen Y, Qiao ZY, Hu HO, Li CN, Zhang J, Sun LZ. Type A aortic dissection during pregnancy and postpartum: Experience in 60 patients over 25 years. J Thorac Cardiovasc Surg. 2026 Jun;171(6):1186-1197.e1. doi: 10.1016/j.jtcvs.2025.12.030. Epub 2026 Jan 9. PMID 41520724

Identifiers

NCT: NCT07672210 · SDH2026006

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗