Respiratory Exacerbations in Children With Bronchopulmonary Dysplasia (BPD): A Case-Control Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Severe Respiratory Exacerbation. Basic parameters: 30 Days — 7 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This is an ambispective observational case-control study evaluating respiratory exacerbations in pediatric patients affected by bronchopulmonary dysplasia (BPD) compared with children without BPD. The study includes a retrospective cohort (January 2020 to September 2025) and a prospective cohort (from study approval to December 2030). Patients admitted to the Pediatric Emergency Department or Pediatric Unit for lower respiratory tract infections will be consecutively enrolled and managed according to standard clinical practice.
Primary outcome measures
- Severe Respiratory Exacerbation [Time frame: Baseline hospitalization]
Eligibility criteria
Inclusion criteria
- Corrected age ≥30 days and ≤7 years Acute lower respiratory tract infection
At least one of:
tachypnea for age SpO2 <94% increased work of breathing Gestational age <32 weeks Diagnosis of bronchopulmonary dysplasia according to NICHD 2018 definition
Exclusion criteria
- Grade ≥3 intraventricular hemorrhage Major congenital heart disease Neuromuscular disorders Chromosomal/genetic syndromes Primary pulmonary diseases Major skeletal dysplasia
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
Italy · 1 center
- IRCCS Azienda Ospedaliero - Universitaria di Bologna, U.O. Pediatria — Bologna
Identifiers
NCT: NCT07666438 · BPD-CC25