Construction of a Prospective Cohort Database for the Perioperative Period of Cardiac Surgery
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Cardiac surgey.
- Who it may be relevant to
- Registry conditions: Valve Heart Disease, Coronary Artery Disease, Coronary Heart Disease, Aortic Diseases. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Cardiovascular disease (CVD) is the leading cause of global morbidity and mortality, with its prevalence increasing significantly from 1990 to 2019. Establishing a comprehensive cardiac surgery database is crucial for exploring perioperative prognostic factors and improving clinical outcomes. This muti-center, prospective observational study aims to construct a prospective cohort database for perioperative cardiac surgery. We plan to enroll adult patients who undergo cardiac surgery with cardiopulmonary bypass at the Second Affiliated Hospital of Zhejiang University and other hospitals from May 1, 2026 to December 31, 2031. Multi-dimensional perioperative data, including laboratory tests, hemodynamics, intraoperative echocardiography, and perioperative medications, will be collected and integrated, along with epidemiological data, clinical diagnosis and treatment information, multimodal data, and follow-up outcomes. An interconnected big data sharing platform will also be built. This database will provide a valuable resource for multi-level researches such as perioperative risk assessment, individualized prevention, precise diagnosis and treatment, and therapeutic efficacy monitoring. It will also help optimize surgical and perioperative management, improve the quality of cardiac surgery, and provide evidence for the refinement of China's healthcare system, ultimately enhancing perioperative safety and rehabilitation efficiency of patients.
Detailed description
1\. Establish a cohort of perioperative surgical patients across multiple medical centers, tracking them from enrollment through 1 year post-surgery, and build a database of data relevant to patient outcomes; 2. Investigate the impact of preoperative psychological and physical factors on short-term postoperative complications in surgical patients, develop predictive models, and conduct prospective validation; 3. Investigate the impact of preoperative psychological, physical, and social factors on long-term postoperative complications; 4. Investigate the incidence of acute and chronic postoperative pain, associated risk factors, and their impact on prognosis; 5. Investigate the optimal perioperative transfusion strategies for allogeneic blood products based on causal relationships, develop predictive models, and validate them.
Interventions
- Procedure Cardiac surgey
Cardiac surgey
Primary outcome measures
- Incidence of major adverse cardiac and cerebrovascular events (MACCE) [Time frame: 4, 12 weeks and 1years after surgery]
- Incidence of Perioperative Transfusion of Allogeneic Blood Products [Time frame: 30 days after surgery]
- Amount of Allogeneic Blood Products Transfused During the Perioperative Period [Time frame: 30 days after surgery]
Secondary outcome measures (10)
- Incidence of perioperative myocardial infarction [Time frame: 4, 12 weeks and 1years after surgery]
- Incidence of New-onset stroke [Time frame: 4, 12 weeks and 1years after surgery]
- Incidence of death [Time frame: 4, 12 weeks and 1years after surgery]
- Incidence of acute kidney injury [Time frame: 7days after suegery]
- Incidence of infectious complications [Time frame: 4, 12 weeks and 1years after surgery]
- Incidence of unplanned hospital readmission within 4 and 12 weeks after surgery [Time frame: 4 and 12 weeks after surgery]
- Length of hospital stay [Time frame: Through patients discharge, an average of 7 days after surgery]
- Hospitalization costs [Time frame: Through patients discharge, an average of 7 days after surgery]
- Quality of life scores [Time frame: at 4, 12 weeks and 1 years after surgery]
- Quality of life scores [Time frame: at 4, 12 weeks and 1 years after surgery]
Eligibility criteria
Inclusion criteria
- Patients undergoing cardiac surgery from May 1, 2026 to December 31, 2031
Exclusion criteria
- Refusal to provide informed consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- 2nd Affiliated Hospital, School of Medicine, Zhejiang University, China — Hangzhou
Identifiers
NCT: NCT07662317 · 2026-0345