Blood Transfusion Risk Factors and Cell Saver Impact in Pediatric Scoliosis Surgery
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: posterior Instrumented Spinal Fusion, Intraoperative Cell Saver Autologous Reinfusion.
- Who it may be relevant to
- Registry conditions: Scoliosis; Spinal Fusion; Blood Transfusion; Operative Blood Loss. Basic parameters: up to 17 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Tunisia
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Risk Factors for Homologous Blood Transfusion and Impact of Cell Saver Use in Pediatric Scoliosis Surgery: A Retrospective Monocentric Study
Overview
Spine surgery for scoliosis correction in pediatric patients is a major procedure associated with a high risk of perioperative blood loss. Homologous blood transfusion carries inherent risks, including immunological reactions, infections, and increased healthcare costs. Identifying high-risk patients is crucial to optimize blood conservation strategies. This retrospective study aims to identify preoperative and intraoperative risk factors associated with homologous red blood cell (RBC) transfusion and to evaluate the quantitative impact of Cell Saver volume reinfusion on reducing homologous transfusion requirements.
Interventions
- Procedure posterior Instrumented Spinal Fusion
Standard surgical correction of scoliosis via a posterior approach with spinal instrumentation and arthrodesis, performed under general anesthesia - Device Intraoperative Cell Saver Autologous Reinfusion
Use of an intraoperative autologous blood salvage device (Cell Saver) during spine surgery. Collected blood is washed, filtered, and reinfused to the patient peroperatively to reduce the need for homologous blood transfusion.
Primary outcome measures
- Proportion of patients requiring perioperative homologous Red Blood Cell (RBC) transfusion [Time frame: : From the start of surgery (anesthesia induction) up to postoperative day 3 (Day 0 to Day 3).]
Secondary outcome measures (2)
- Blood conservation rate achieved by intraoperative autologous blood salvage [Time frame: Intraoperative period (from skin incision to skin closure)]
- Total volume of homologous Red Blood Cells (RBC) transfused. [Time frame: From the start of surgery up to postoperative day 3 (Day 0 to Day 3).]
Eligibility criteria
Inclusion criteria
- Patient aged under 18 years (< 18 years old).
- Programmed surgical correction for scoliosis (including idiopathic, neuromuscular, and congenital etiologies).
- Instrumented surgery involving posterior spinal arthrodesis.
Exclusion criteria
- Revision spine surgeries.
- Known constitutional hemostasis disorders.
- Non-orthopedic spine surgeries.
- Missing core clinical or transfusion data.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Tunisia · 1 center
- Bechir Hamza Children Hospital — Tunis
Identifiers
NCT: NCT07661589 · 26/2026