Corneal Epithelial Thickness Mapping by Anterior Segment Optical Coherence Tomography in Patients With Refractive Errors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Myopia, Hyperopia, Astigmatism, Emmetropia. Basic parameters: 18 years — 99 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Egypt
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This study evaluates corneal epithelial thickness using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. It aims to assess the relationship between epithelial thickness patterns and different types of refractive errors.
Detailed description
Refractive errors are among the most common ocular conditions affecting visual acuity. Corneal epithelial thickness has been suggested to play a role in the optical properties of the eye and may vary among different refractive states. This observational study aims to evaluate corneal epithelial thickness mapping using anterior segment optical coherence tomography (AS-OCT) in patients with refractive errors. Patients will be assessed and categorized according to their refractive status, and epithelial thickness measurements will be obtained and analyzed. The study seeks to investigate potential correlations between epithelial thickness distribution and different types of refractive errors to enhance understanding of corneal biomechanics in refractive conditions.
Primary outcome measures
- Measurement of corneal epithelial thickness using AS-OCT [Time frame: At baseline during a single study visit when participants undergo AS-OCT examination.]
Secondary outcome measures (4)
- Comparison of epithelial thickness between myopic and hyperopic eyes [Time frame: At baseline (single visit)]
- Comparison of epithelial thickness in eyes with and without astigmatism [Time frame: At baseline (single visit)]
- Corneal epithelial thickness asymmetry across corneal regions and inter-eye comparison [Time frame: At baseline (single visit)]
- Comparison of epithelial thickness in low and high refractive errors [Time frame: At baseline (single visit)]
Eligibility criteria
Inclusion criteria
- Age ≥ 18 years-
- Patients diagnosed with myopia or hyperopia by refraction
- Clear cornea with no evidence of corneal pathology
- Ability to undergo reliable anterior segment imaging
Exclusion criteria
- Inability to fixate or follow instructions
- Family history of keratoconus
- Glaucoma,Cataract
- Previous ocular surgery including refractive surgery
- Keratoconus or suspected corneal ectasia
- Corneal opacities or scars
- Contact lens wear within the last two weeks
- Ocular trauma
- systemic disease affecting the cornea ( Such as diabetes)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Egypt · 1 center
- Sohag University Hospital — Sohag
Identifiers
NCT: NCT07647146 · Soh-Med-26-5-7MS