Evaluation of Muscle Oxygen With MRI
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Compression and Contraction.
- Who it may be relevant to
- Registry conditions: Muscle Oxygenation. Basic parameters: 20 years — 64 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effect of External Pressure and Muscle Contraction on Soft Tissue Oxygenation Measured With Functional MRI
Overview
Demonstration of soft tissue hypoxia on MRI using external compression and muscle contraction.
Detailed description
Participant will undergo a single MRI examination. Standard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a standard brace soft foam attached; blood pressure cuff will be partially inflated. Participant will also be asked to lift MRI compatible 10 lb. weight. Muscle oxygenation will be actively measured using MRI. No medications are being given, and no invasive devices are being used.
Interventions
- Procedure Compression and Contraction
Standard orthopedic Sarmiento brace/ shell applied to participant's arm. Inside the brace will be a standard blood pressure cuff with a soft foam attached. Pressure will be applied intermittently with blood pressure cuff. Participant will also be asked to lift MRI compatible 10 lb. weight.
Primary outcome measures
- Muscle oxygen level [Time frame: Day 1, during procedure]
Secondary outcome measures (1)
- Deep tissue oxygen level [Time frame: Day 1, during procedure]
Eligibility criteria
Inclusion criteria
- Alert and oriented.
- Able to lift 10lbs. and hold for 30 seconds
- Not claustrophobic.
- Intact sensation in right upper extremity.
Exclusion criteria
- Latex allergy or allergy to isopropyl alcohol.
- Skin injury or decreased sensation on right upper extremity.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- Mount Sinai Hess Center — New York
Identifiers
NCT: NCT07638384 · STUDY-26-00124