Streamlined Treatment and Evidence-based Adolescent Counseling and Medication Support (STREAMS)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Streamlined Suubi+Adherence, Streamlined Interpersonal Psychotherapy Groups (IPT-G).
- Who it may be relevant to
- Registry conditions: Depression in Adolescence. Basic parameters: 15 years — 19 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Combination interventions to address mental health and adherence to HIV care in low- and middle-income countries (LMICs), are crucial to achieving the UNAIDS 95-95-95 targets as one in four adolescents living with HIV (ALWHIV) experience poor mental health and this contributes to suboptimal medication adherence and lack of viral suppression. Yet few evidence-based mental health and adherence interventions have been evaluated in sub-Saharan Africa (SSA), the region where the majority of the 1.7 million ALWHIV reside. STREAMS will determine if our streamlined combination intervention approach to mental health screening, provision of evidence-based interpersonal psychotherapy groups (IPT-G), and evidence-based family strengthening, and medication counseling is feasible and efficacious for ALWHIV in Uganda.
Interventions
- Behavioral Streamlined Suubi+Adherence
Participants in this intervention arm will receive: * Financial literacy training * Youth savings accounts The intervention aims to strengthen economic stability and support long-term treatment adherence and psychosocial well-being. - Behavioral Streamlined Interpersonal Psychotherapy Groups (IPT-G)
* Participants in the IPT-G intervention arms will attend: * Six weekly group counseling sessions, * Conducted in groups of approximately 6-10 adolescents, * Facilitated by trained StrongMinds counselors. The sessions will focus on: * Emotional wellbeing * Relationships * Coping with stress * Grief and loss * Social support * Problem-solving skills
Primary outcome measures
- Depressive symptomatology [Time frame: Baseline to 24 months post-intervention initiation]
Secondary outcome measures (1)
- Viral Load [Time frame: Baseline to 12-months post intervention initiation]
Eligibility criteria
Inclusion criteria
- Living with HIV with confirmation by medical report and aware of their status
- Living within a family (defined broadly, not necessarily with biological parents); - - Between the ages of 15 to 19 years
- Prescribed ART
- Score a 10 or greater on the PHQ-9
Exclusion criteria
- an inability to understand study procedures and participant rights as assessed during informed consent/assent process with the adolescent or caregiver.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07637058 · R01MH140406 · R01MH140406