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COMPARISON OF AIRWAY NERVE BLOCK VERSUS NEBULIZED LIDOCAINE ON HEMODYNAMIC RESPONSES DURING AWAKE FIBEROPTIC INTUBATION

No phase Interventional Blood Pressure After Nerve Block Hemodynamic Stability During Awake Intubation

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Nebulized Lidocaine, Nerve Block.
Who it may be relevant to
Registry conditions: Blood Pressure After Nerve Block, Hemodynamic Stability During Awake Intubation. Basic parameters: 18 years — 65 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Pakistan
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

COMPARISON OF AIRWAY NERVE BLOCK VERSUS NEBULIZED LIDOCAINE ON HEMODYNAMIC RESPONSES DURING AWAKE FIBEROPTIC INTUBATION, A RANDOMIZED CONTROLLED TRIAL

Overview

This prospective randomized controlled trial aims to compare the effectiveness of airway nerve blocks versus nebulized lidocaine in attenuating hemodynamic responses during awake fiberoptic intubation in adult patients with anticipated difficult airways. Eighty patients undergoing elective surgery requiring awake fiberoptic intubation will be randomly assigned to receive either airway nerve blocks (glossopharyngeal and transtracheal blocks with lidocaine) or nebulized lidocaine. The primary outcome will be changes in heart rate and mean arterial pressure during and after intubation. Secondary outcomes include intubation conditions, patient comfort, cough severity, intubation time, and procedure-related complications. The study aims to identify the most effective airway anesthesia technique for maintaining hemodynamic stability and improving patient tolerance during awake fiberoptic intubation.

Interventions

  • Drug Nebulized Lidocaine
    Participants will receive 4% lidocaine administered via nebulization for 15 minutes before awake fiberoptic intubation to provide topical airway anesthesia and suppress airway reflexes during the procedure.
  • Procedure Nerve Block
    Participants will receive airway anesthesia using bilateral glossopharyngeal nerve block and transtracheal block with 2% lidocaine before awake fiberoptic intubation to provide airway anesthesia and suppress airway reflexes during the procedure.

Primary outcome measures

  • Mean Arterial Pressure (MAP) Change During Awake Fiberoptic Intubation [Time frame: Baseline to 5 minutes after intubation.]
  • Heart Rate Change During Awake Fiberoptic Intubation [Time frame: Baseline to 5 minutes after intubation.]
Secondary outcome measures (5)
  • Intubation Time [Time frame: During the intubation procedure.]
  • Patient Comfort Score [Time frame: Immediately after completion of awake fiberoptic intubation.]
  • Cough Severity Score [Time frame: During the intubation procedure.]
  • Successful Intubation Rate [Time frame: From intervention administration until 5 minutes after intubation.]
  • Procedure-Related Complications [Time frame: From intervention administration until 5 minutes after intubation.]

Eligibility criteria

Inclusion criteria

Adults aged 18 to 65 years. American Society of Anesthesiologists (ASA) physical status I-III. Scheduled for elective surgery requiring awake fiberoptic intubation. Anticipated difficult airway. Able and willing to provide written informed consent

Exclusion criteria

Known allergy or hypersensitivity to lidocaine or other local anesthetics. Coagulopathy or bleeding disorders. Severe respiratory disease. Hemodynamic instability. Pregnancy. Refusal to participate in the study. Inability to cooperate with awake fiberoptic intubation or study procedures

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Treatment

Study locations

Pakistan · 1 center
  • Mayo Hospital, Lahore — Lahore

Identifiers

NCT: NCT07627100 · Nerve Block Intubation

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗