The Extraordinary Endurance of the Human Species
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Intensive training.
- Who it may be relevant to
- Registry conditions: Healthy Volunteers. Basic parameters: 25 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
We hypothesize, based on field and scientific data, that setting a very ambitious goal such as completing a mountain ultra-marathon could motivate sedentary and inactive individuals not only to begin training but also to follow a progressive yet extremely ambitious program that has not yet been studied comprehensively. Indeed, the effects of intense and prolonged endurance training (18 months) on the health and performance of completely sedentary individuals have never been investigated exhaustively.
Interventions
- Behavioral Intensive training
participants will follow individualized coaching: starting at 5-6 hours per week and progressing to 7-10 hours (rarely 15 hours) per week before mountain ultra marathon
Primary outcome measures
- Transition from sedentary lifestyle to regular activity and completion of a 100 km ultra-trail [Time frame: up to 18 months]
Secondary outcome measures (2)
- Safety and tolerance of progressive endurance training [Time frame: Weekly reporting during the 18-month intervention period]
- Feasibility and adherence to the endurance training program [Time frame: up to 18 months]
Eligibility criteria
Inclusion criteria
- Affiliation to social security.
- Informed consent signed.
- Male or female, aged 25-50.
- Sedentary (>6h/day sitting) and inactive (no regular training), assessed by GPAQ questionnaire.
Exclusion criteria
- Chronic joint or cardiac diseases.
- Neurological disorders.
- Legal protection status.
- Moderate to severe depression (BDI-13 > 7) or use of antidepressants/anxiolytics.
- Use of banned substances.
- Excessive alcohol or caffeine consumption.
- Pregnancy.
- Inability to understand or consent.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Other
Study locations
France · 1 center
- CHU de Saint-Etienne — Saint-Etienne
Identifiers
NCT: NCT07626593 · 25CH172 · ANSM