Systemic Inflammatory Markers In Vocal Cord Lesions
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Laryngeal polyps, Laryngeal nodules, Laryngeal cysts, Reinke's edema.
- Who it may be relevant to
- Registry conditions: Laryngeal Lesions, Systemic Inflammatory Process. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Comparison Of Sysstemic Inflammatory Markers And Panimmune-Inflammatory Values In Patients With Beningn, Premalingnant And Malingnant Vocal Cord Lesions
Overview
The aim of this study is to evaluate the levels of systemic inflammatory markers such as PIV, SII, and NPAR in patients with benign and premalignant laryngeal lesions and to determine the diagnostic accuracy of these values using ROC analysis.
Detailed description
Benign laryngeal lesions are generally nodules, polyps, or cysts that form due to overuse of the voice or vocal cord trauma. Reinke's edema, also within this group, is a benign laryngeal condition characterized by the accumulation of gelatinous fluid in the superficial lamina propria of the vocal cords. It is usually associated with chronic irritation, particularly smoking, and is frequently seen in middle-aged individuals with a long history of tobacco use. Previous experimental studies have shown that cigarette smoke triggers inflammatory responses in vocal cord fibroblasts and increases the production of inflammatory mediators. The cellular and systemic inflammatory processes triggered by irritation due to chronic smoking are still not fully understood. In recent years, systemic inflammation markers derived from routine hemogram parameters have attracted attention as low-cost and reliable potential biomarkers in various inflammatory and neoplastic diseases. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), hemoglobin-eosinophil ratio (HEO), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV), as well as more comprehensive indices reflecting both inflammatory and nutritional status such as Neutrophil-Albumin Ratio (NPAR) and HALP (Hemoglobin, Albumin, Platelet Ratio), are inexpensive and readily available indicators of systemic inflammation. However, a review of the literature reveals a lack of studies examining the relationship between benign and malignant laryngeal lesions and systemic inflammation through these comprehensive indices (PIV and NPAR). The aim of this study is to evaluate the levels of systemic inflammatory markers such as PIV, SII, and NPAR in patients with benign and premalignant laryngeal lesions and to determine the diagnostic accuracy of these values using ROC analysis.
Interventions
- Other Laryngeal polyps
Bening laryngeal lesions - Other Laryngeal nodules
Bening laryngeal lesions - Other Laryngeal cysts
Bening laryngeal lesions - Other Reinke's edema
Bening laryngeal lesions - Other Papillomas
Premalign laryngeal lesions - Other Dysplasia
Premalign laryngeal lesions - Other High-risk premalignant lesions
Premalign laryngeal lesions - Other Malignant vocal cord lesions
Malign laryngeal lesions - Other Asymptomatic smokers without vocal cord lesions
None laryngeal lesions
Primary outcome measures
- Determining the diagnostic accuracy of PIV [Time frame: Postoperative 1 month]
Secondary outcome measures (6)
- Determining the diagnostic accuracy of NLR [Time frame: Postoperative 1 month]
- Determining the diagnostic accuracy of PLR [Time frame: Postoperative 1 month]
- Determining the diagnostic accuracy of HEO [Time frame: Postoperative 1 month]
- Determining the diagnostic accuracy of SII [Time frame: Postoperative 1 month]
- Determining the diagnostic accuracy of NPAR [Time frame: Postoperative 1 month]
- Determining the diagnostic accuracy of HALP [Time frame: Postoperative 1 month]
Eligibility criteria
Inclusion criteria
- Patients aged 18 years and older
- Patients with a diagnosis of vocal cord lesion via endoscopic or surgical means
- Patients with complete blood count and albumin data in their hospital records
Exclusion criteria
- Acute infection
- Autoimmune disease
- Other malignancy
- Steroid use
- Hematological disease
- Systemic inflammatory disease
- Missing laboratory data
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
Turkey (Türkiye) · 1 center
- University of Health Sciences, Antalya Training and Research Hospital — Antalya
Publications
- Pan L, Yu Z, Xiang WX, Sun SR, Li JX, Deng YK, Wang MC, Zhong JX, Huang K, Gao PS, Zhu LP, Yao Y, Liu Z. Cigarette smoke-induced epithelial cell ferroptosis promotes neutrophilic inflammation in patients with nasal polyps. J Allergy Clin Immunol. 2025 Jun;155(6):1882-1897. doi: 10.1016/j.jaci.2025.02.034. Epub 2025 Mar 12. PMID 40086488
- Guven DC, Erul E, Yilmaz F, Yasar S, Yildirim HC, Ercan F, Kaygusuz Y, Cayiroz K, Ucdal MT, Yesil F, Yazici G, Cengiz M, Gullu I, Aksoy S. The association between pan-immune-inflammation value and survival in head and neck squamous cell carcinoma. Eur Arch Otorhinolaryngol. 2023 May;280(5):2471-2478. doi: 10.1007/s00405-022-07804-x. Epub 2022 Dec 24. PMID 36565325
Identifiers
NCT: NCT07626125 · 7/14