The Implementation of Genetic Risk for Colorectal Cancer Screening
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp. Basic parameters: 45 years — 75 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Prospective Trial for the Implementation of Genetic Risk for Colorectal Cancer Screening
Overview
The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1. How does knowledge of a patient's genetic risk for colorectal cancer affect the uptake of initial screening colonoscopies? 2. How do colonoscopy outcomes compare between genetic risk groups?
Primary outcome measures
- Number of scheduled colonoscopies in each genetic risk group [Time frame: One year following enrollment]
Secondary outcome measures (1)
- Number of polyps and/or adenomas found through colonoscopy in each genetic risk group [Time frame: One year following enrollment]
Eligibility criteria
Inclusion criteria
\- Due for initial screening colonoscopy per current guidelines
Exclusion criteria
- Prior colonoscopy
- Prior personal history of colorectal cancer or inflammatory bowel disease
- Medical contraindications to colonoscopy/sedation
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- Endeavor Health — Evanston
Identifiers
NCT: NCT07621757 · IRB2026-0064