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Not yet recruiting NCT07619469

Motion Sickness Severity and Sensorimotor Performance

— Observational Motion Sickness Somatosensory Disorders Dizziness

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Standardized Sensorimotor Assessment and Motion Sickness Provocation Protocol.
Who it may be relevant to
Registry conditions: Motion Sickness, Somatosensory Disorders, Dizziness. Basic parameters: 18 years — 40 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

The Relationship of Balance, Proprioception, Coordination, and Reaction Time Measurements With Motion Sickness Severity in Individuals With Motion Sickness: A Cross-Sectional Study

Overview

Background: Motion sickness (MS) is a common syndrome characterized by autonomic and behavioral symptoms, such as nausea and dizziness, resulting from exposure to motion stimuli. Its pathophysiology is closely linked to sensory conflict and postural instability theories. While previous studies suggest that postural control, proprioception, and reaction times are affected in individuals susceptible to MS, there is a lack of comprehensive, comparative research evaluating all these parameters concurrently within the same cohort using standardized methods. Objective: This study aims to systematically measure balance, proprioceptive sensitivity, coordination, and reaction time parameters, and quantitatively analyze their relationship with motion sickness severity. Methodology: In this prospective, cross-sectional study, at least 41 participants aged 18-40 with motion sickness will be recruited. Participants will undergo motion sickness susceptibility and severity grading using the Motion Sickness Susceptibility Questionnaire Short Form (MSSQ-SF) and the Graybiel Scale. Objective assessments will include static and dynamic balance testing (ProKin®), knee joint position sense (Clinometer app), manual dexterity and dynamic balance coordination (Nine-Hole Peg Test, Tandem Walk, Romberg Test), and upper/lower extremity reaction time measurements (BlazePod system).

Interventions

  • Other Standardized Sensorimotor Assessment and Motion Sickness Provocation Protocol
    Participants will undergo a standardized battery of sensorimotor assessments, including static/dynamic balance tracking, knee joint position sense testing, manual dexterity/coordination tasks, and upper/lower extremity reaction time measurements, alongside a controlled motion sickness provocation session using a randomized chair-rotation protocol."

Primary outcome measures

  • Motion Sickness Severity (Graybiel Score) [Time frame: 1 hour]
  • Static Balance [Time frame: 1 hour]
  • Dynamic Balance Performance [Time frame: 1 hour]
Secondary outcome measures (4)
  • Knee Joint Proprioception [Time frame: 1 hour]
  • Nine-Hole Peg Test (9HPT) Completion Time [Time frame: 1 hour]
  • Tandem Walk Test Error Count [Time frame: 1 hour]
  • Visual Reaction Time [Time frame: 1 hour]

Eligibility criteria

Inclusion criteria

  • Individuals aged between 18 and 40 years.
  • Diagnosed with motion sickness according to the Motion Sickness -Susceptibility Questionnaire Short Form (MSSQ-SF).
  • Normal hearing acuity.
  • No history of acute or chronic vestibular disease, other than motion sickness.
  • Normal or corrected-to-normal vision.
  • Adequate physical capability to fully perform the measurement protocols, including balance, proprioception, coordination, and reaction time tests.

Exclusion criteria

  • Presence of any physical or orthopedic problem that could interfere with testing.
  • History of acute or chronic instability, unsteadiness, or vertigo.
  • Severe visual impairment.
  • History of prior ear surgery.
  • Presence of any neurological condition or disorder.
  • History of migraines.
  • Current use of medications that could affect balance or vestibular function (e.g., vestibular suppressants, sedatives).
  • Use of alcohol or psychoactive substances within the last 48 hours prior to testing.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07619469 · 25

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗