Right Ventricular Function and Respiratory Acidosis After Cardiac Surgery
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Not applicable- observational study.
- Who it may be relevant to
- Registry conditions: Respiratory Acidosis in ICU Patients, Right Ventricular (RV) Dysfunction, Hemodynamic Changes, Mechanical Ventilation. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Canada
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Right heart dysfunction remains a frequent cause of morbidity and mortality after cardiac surgery. Respiratory acidosis, particularly when accompanied by hypoxemia, plays a significant role in right heart failure, primarily by increasing right ventricular afterload through pulmonary vasoconstriction and elevated pulmonary arterial pressures. This phenomenon leads to increased right ventricular workload, causing dilation, decreased contractility, and ultimately right heart failure. The study aims to evaluate the effect of respiratory acidosis on right ventricular function after cardiac surgery.
Detailed description
Post hoc analysis of data from two separate studies previously approved by the Research Ethics Board NCT05886413 and NCT06826794. A stratification according to respiratory acidosis defined by a pH \<7.35 with PaCO₂ \>45mmHg on the first arterial blood gas analysis at the intensive care unit arrival will be done.
Interventions
- Other Not applicable- observational study
No intervention
Primary outcome measures
- Right ventricular function per central hemodynamic assessment [Time frame: At intensive care unit admission - within the first 4 hours]
Secondary outcome measures (5)
- Intensive care unit length of stay [Time frame: Up to 28 days]
- Mechanical ventilation duration [Time frame: Day 28]
- Vasopressor duration [Time frame: Day 28]
- Acute renal failure [Time frame: Day 28]
- Mortality [Time frame: Day 28]
Eligibility criteria
Inclusion criteria
- Previously included and complete study NCT05886413 or NCT06826794
Exclusion criteria
- Absence of one or more of the following hemodynamic measurements: systolic or diastolic pulmonary artery pressure, central venous pressure, cardiac output
- Absence of arterial blood gas on arrival to the intensive care unit
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Canada · 1 center
- Institut universitaire de cardiologie et de pneumologie de Quebec - Universite Laval — Québec
Identifiers
NCT: NCT07619274 · 2027-4604