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Recruiting NCT07611890

Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial

Phase IV Interventional Laryngoscopic Stress Response Dexmedetomidine Lignocaine

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: IV dexmedetomidine, IV Lignocaine.
Who it may be relevant to
Registry conditions: Laryngoscopic Stress Response, Dexmedetomidine, Lignocaine. Basic parameters: 18 years — 65 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Pakistan
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Comparison of Intravenous Dexmedetomidine and Lignocaine in Reducing Hemodynamic Responses During Laryngoscopy and Endotracheal Intubation In Patients Undergoing Cardiac Surgery at Rawalpindi Institute Of Cardiology- A Randomized Controlled Trial

Overview

After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication. Each participant will receive a unique study number to protect privacy. Participants will be randomly assigned to receive one of the study medications using a chance-based method.The study medication will be administered through a vein before placement of the breathing tube. Blood pressure and pulse rate will be measured before the procedure and at several time points after the breathing tube is inserted.

Detailed description

After confirming eligibility, written informed consent will be obtained and each participant will be assigned a unique study ID to maintain confidentiality. Participants will be randomly allocated using a computer-generated random sequence implemented through the lottery method, with assignments placed in sealed opaque envelopes opened on the day of surgery. The study medication will be administered intravenously according to the study protocol before laryngoscopy and endotracheal intubation. Mean arterial pressure and heart rate will be recorded at baseline and at 1, 3, 5, and 10 minutes after intubation. Demographic information and study-related observations will be documented in a structured data collection form.

Interventions

  • Drug IV dexmedetomidine
    0.5 Mcg/kg of Dexmedetomidine will be given 10 minutes before laryngoscopy
  • Drug IV Lignocaine
    Patients will be given 1.5 mg/kg of Lignocaine 3 minutes before laryngoscopy

Primary outcome measures

  • Mean Arterial Pressure [Time frame: It will be expressed in millimeters of mercury (mmHg) and measured using an arterial catheter immediately before intubation and then at 1,3,5 and 10 minutes after intubation.]
  • Heart Rate [Time frame: It will be expressed as number of heart beats per minute and measured using pulse oximeter immediately before intubation and then at 1,3,5 and 10 minutes after intubation.]

Eligibility criteria

Inclusion criteria

American Society of Anesthesiologists (ASA) physical status III-IV. Patients who are at risk of cardiovascular events

Exclusion criteria

  • Patients with known hypersensitivity to dexmedetomidine and Lignocaine.
  • Patients on medications that could interfere with the study (e.g., beta-blockers, calcium channel blockers).
  • Pregnant or lactating women.
  • Patients with a history of airway anomalies or difficult intubation.

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Double blind
Primary purpose
Prevention

Study locations

Pakistan · 1 center
  • Rawalpindi Institute of Cardiology — Rawalpindi

Publications

  • Dube S, Gosavi K, Admane G. Comparative study of Dexmedetomidine, Lignocaine and their combination for the attenuation of hemodynamic response during laryngoscopy and intubation [Internet]. Indian J Clin Anaesth. 2022 [cited 2026 May 21];9(1):27-31. Available from: https://doi.org/10.18231/j.ijca.2022.007

Identifiers

NCT: NCT07611890 · RIC/RERC/13/25

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗