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Not yet recruiting NCT07608471

QLF and Digital Imaging for Caries Activity Assessment After Orthodontic Treatment

— Observational Dental Caries White Spot Lesions Caries Lesion Activity Post-Orthodontic Enamel Demineralization

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Dental Caries, White Spot Lesions, Caries Lesion Activity, Post-Orthodontic Enamel Demineralization. Basic parameters: 11 years — 46 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Center list to be confirmed — check the primary protocol.
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Diagnostic Performance of Smartphone, 3D Imaging, QLF-D, and ICDAS Clinical Criteria for Non-Cavitated Caries Activity Assessment in Post-Orthodontic Patients Under a Preventive Program

Overview

This prospective longitudinal observational study aims to evaluate the diagnostic performance and agreement of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS clinical criteria for assessing non-cavitated caries lesion activity in post-orthodontic patients under a preventive follow-up program. Thirty participants aged 11 to 46 years with active initial caries lesions will be followed for three months. Clinical examinations, QLF-D imaging, smartphone photographs, and intraoral 3D scans will be obtained at baseline and follow-up visits combined with professional prophylaxis and oral hygiene reinforcement. The study will analyze changes in lesion activity, fluorescence parameters, and surface characteristics over time, as well as the agreement and diagnostic performance among the evaluated methods.

Detailed description

This prospective longitudinal observational study will evaluate the agreement and diagnostic performance of Smartphone photography, intraoral 3D imaging, Quantitative Light-Induced Fluorescence Digital (QLF-D), and ICDAS clinical criteria for assessing non-cavitated caries lesion activity in post-orthodontic patients.

Participants presenting active initial caries lesions on vestibular tooth surfaces will undergo clinical examinations, QLF-D imaging, smartphone photographs, and intraoral 3D scans at baseline and during a three-month preventive follow-up program. Professional prophylaxis and oral hygiene reinforcement will be performed throughout the study period.

Changes in clinical lesion activity, fluorescence parameters, and topographic characteristics will be analyzed to determine the monitoring capacity, agreement, and diagnostic performance of the evaluated methods. Patient acceptance of the diagnostic technologies will also be assessed.

Primary outcome measures

  • Diagnostic Agreement Measured by Weighted Kappa Between ICDAS Clinical Assessment and QLF-D, Smartphone Photography, and Intraoral 3D Imaging for Non-Cavitated Caries Lesion Activity [Time frame: Baseline, 3 months and 6 months]

Eligibility criteria

Inclusion criteria

  • Participants aged 11 to 46 years
  • Completed fixed orthodontic treatment
  • Presence of at least four active non-cavitated caries lesions (ICDAS 1-3)
  • Lesions located on vestibular surfaces of anterior teeth and/or premolars
  • Ability to attend follow-up visits during the three-month study period
  • Signed informed consent and/or assent form

Exclusion criteria

  • Systemic conditions affecting salivary flow or enamel structure
  • Extensive cavitated lesions requiring restorative treatment
  • Ongoing orthodontic treatment
  • Use of medications that significantly affect oral conditions
  • Inability to cooperate with imaging procedures or follow-up visits

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

Center list to be confirmed — check the primary protocol.

Identifiers

NCT: NCT07608471 · UEB CIE2025-108

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗