Thyroid Dysfunction in Elderly
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Geriatric Diseases. Basic parameters: from 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Thyroid Dysfunction and it's Association With Comorbidities and Polypharmacy Among Older Adults in a Tertiary Care Hospital, Assiut_Egypt
Overview
Thyroid dysfunction in elderly
Detailed description
Thyroid dysfunction is a common endocrine disorder among older adults, with prevalence increasing due to age-related physiological changes and the high burden of chronic diseases (1).
It is estimated that 20-30% of individuals aged 60 years and above have some form of thyroid dysfunction, particularly hypothyroidism (2).
Aging affects thyroid hormone secretion, metabolism, and tissue responsiveness, which may alter thyroid function tests even in the absence of overt disease (3).
In elderly patients, thyroid disorders often present with nonspecific or atypical manifestations such as fatigue, cognitive decline, and weight changes, leading to underdiagnosis (4).
Subclinical thyroid dysfunction is also highly prevalent and frequently detected incidentally (5).
Older adults commonly suffer from multiple comorbidities involving different organ systems, which complicates both clinical presentation and interpretation of thyroid function tests (6).
Thyroid dysfunction has been associated with adverse outcomes, including cardiovascular disease, atrial fibrillation, and increased mortality (7).
Polypharmacy is highly prevalent in this population, with many patients receiving five or more medications concurrently (8).
Several drugs can interfere with thyroid function or its laboratory assessment (9).
Despite the clinical importance of this issue, limited data are available in our locality regarding the combined effect of comorbidities and polypharmacy on thyroid function in older adults. Therefore, this study aims to investigate this association.
Primary outcome measures
- prevalence of thyroid dysfunction in older adult patients [Time frame: at baseline]
- assess association between comorbidities and polypharmacy on thyroid function among older adult patients [Time frame: at baseline]
Eligibility criteria
inclusion criteria: Older adult patients aged 60 years or older attending the internal medicine, family medicine, and Geriatric department, both males and females.
exclusion criteria: patients previously diagnosed with thyroid dysfunction or currently receiving thyroid related treatment, patients with a history of thyroid malignancy, or with end stage organ failure
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-crossover
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07606560 · Thyroid Dysfunction in Elderly