Human Neural Correlates of Multi-Timescale Inference
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Decision-making task, eye tracking.
- Who it may be relevant to
- Registry conditions: Cognition, Brain Activity. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Neuronal Mechanisms of Human Cognition
Overview
Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period.
Detailed description
The investigators will analyze recorded neural activity, eye movements, and behavioral responses from epilepsy patients undergoing intracranial monitoring with clinically-relevant microelectrodes in hippocampus that perform a decision-making task. The participants will perform 1 session of the task during their monitoring period. Behavioral responses will be fit to inference models to identify strategies subjects use, and neural recordings (neuronal firing and low frequency activity) will be correlated with task features by comparing results to those produced by randomized (bootstrapped) data. Neural activity and corresponding behavioral strategies for each participant will be used to refine theoretical recurrent neural network models of hippocampal engagement in multi-timescale inference.
Interventions
- Behavioral Decision-making task
Patients will be asked to play a decision-making game in which they hear a tone and must identify its source. - Behavioral eye tracking
Patients will have simultaneous eye-tracking performed while playing the decision-making game
Primary outcome measures
- Pupil size changes with respect to task features [Time frame: continuous recording during task, up to 30 minutes]
- Behavioral Responses [Time frame: Approximately 10 seconds per trial, up to 30 minutes total]
- Intracranial electrode recordings to measure changes in brain activity during decision making [Time frame: duration of the task, approximately 30 minutes]
Eligibility criteria
Inclusion criteria
- Epilepsy patients undergoing intracranial electrode monitoring for uncontrolled seizures.
- no lesions identified in the participants' brains
- capable of giving consent
Exclusion criteria
- seizure activity during task recording
- electrodes in regions of interest are identified to be the seizure focus
- task performance outside of the normal range as determined from online studies with healthy participants
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
United States · 1 center
- University of Colorado Anschutz — Aurora
Identifiers
NCT: NCT07606469 · 25-1284 · R00NS127855