Epicardial Fat Tissue and Cardiometabolic Risk in Russian and Asian Populations
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Epicardial Fat Tissue (EFT), Chronic Non-Communicable Diseases (NCDs), Visceral Obesity. Basic parameters: 50 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Russia
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Epicardial Fat Tissue Assessed by Echocardiography in Russian and Asian Populations: Association With Chronic Non-Communicable Diseases and Risk Factors
Overview
Visceral obesity is a well-established risk factor for the development of chronic non-communicable diseases (NCDs). Epicardial fat tissue (EFT) is located on the surface of the myocardium and may directly affect cardiac function and contribute to structural and functional remodeling. According to the literature, increased EFT thickness is associated with a wide range of NCDs, disease severity, and prognosis. The aim of this study is to investigate the associations between EFT thickness and clinical and anamnestic parameters, as well as to evaluate the prognostic value of this parameter in patients aged 50-70 years from the Russian Federation, Kazakhstan, Uzbekistan, and Kyrgyzstan.
Detailed description
The study is designed to:
1. Assess physical examination findings, laboratory parameters, and comorbidities; 2. Evaluate transthoracic echocardiography parameters; 3. Analyze associations between EFT thickness and clinical and anamnestic characteristics; 4. Determine threshold values of EFT thickness associated with structural and functional myocardial remodeling; 5. Conduct follow-up via telephone to assess study endpoints; 6. Evaluate the prognostic value of EFT thickness with respect to a composite endpoint.
Primary outcome measures
- Composite endpoint - all-cause mortality - hospitalizations - major adverse cardiovascular events (MACE) [Time frame: 12 months]
Eligibility criteria
Inclusion criteria
- Patients aged 50-70 years undergoing transthoracic echocardiography in inpatient or outpatient settings;
- Ability and willingness to provide informed consent.
Exclusion criteria
- Refusal to sign informed consent;
- Inability to perform transthoracic echocardiography or poor image quality;
- Severe psychiatric disorders.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Russia · 1 center
- National Medical Research Center for Therapy and Preventive Medicine — Moscow
Identifiers
NCT: NCT07604610 · 02-02/26