Not yet recruiting NCT07604207
Multi-organ Imaging of Microvascular and Metabolic Function
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: 18F-FDG, Positron Emission Tomography (PET).
- Who it may be relevant to
- Registry conditions: Healthy Subjects (HS), Cardiovascular Diseases (CVD). Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
What if heart disease starts outside the heart? This research will study how to simultaneously assess brain and body physiology, how they are jointly related to heart function, and how their response to physical and mental stress differs in patients with heart disease.
Interventions
- Drug 18F-FDG
Dynamic 18F-FDG PET - Device Positron Emission Tomography (PET)
Panorama GS PET/CT
Primary outcome measures
- Blood flow responses [Time frame: During the procedure]
Secondary outcome measures (1)
- Glucose metabolism responses [Time frame: During the scan]
Eligibility criteria
Inclusion criteria
- Adults aged 18 years and older
- For patients with cardiovascular disease: Documented diagnosis of ischemic heart disease based on standard clinical, radiologic, and/or histopathologic criteria, as documented in the medical record; or a clinical nuclear cardiac stress PET test within 1 year.
- For healthy subjects: No diagnosis of cardiometabolic disease, cancer, or other major disease within the past 5 years
Exclusion criteria
- Contraindications to PET due to:
- Research-related radiation exposure exceeding current MGB Radiology Department guidelines (i.e., 50 mSv in the prior 12 months);
- Inability to lie comfortably on the bed inside the scanner;
- Body weight > 300 lbs (weight limit of the scanner table);
- Pregnancy or breastfeeding;
- Individuals with fasting plasma glucose level of >200 mg/dL;
- Claustrophobia
- Employed under the direct supervision of the PI conducting the research.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07604207 · 2026P001016