Periodontal Disease in Patients With Lynch Syndrome
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: periodontal charting for the diagnosis of periodontitis.
- Who it may be relevant to
- Registry conditions: Lynch Syndrome, Periodontal Disease. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Periodontal Disease in Patients With Lynch Syndrome: a Retrospective Observational, Monocentric Case-control Study
Overview
The field of human microbiome research has undergone a revolution in its approach toward understanding how microorganisms influence the physiology of their host 1. The influence of the oral microbiota is not confined to this location 2. Periodontitis is a "chronic inflammatory disease associated with dysbiotic plaque biofilms and characterized by a progressive destruction of the tooth supporting apparatus"3. Given these observations, the central research question of the present study is to determine the prevalence of periodontitis in patients with Lynch syndrome (LS) compared with reference prevalence estimates from the general population40.
Interventions
- Other periodontal charting for the diagnosis of periodontitis
No additional interventions
Primary outcome measures
- Prevalence of periodontitis in Lynch Syndrome subjects. [Time frame: Retrospective assessment at study enrollment]
Eligibility criteria
Inclusion criteria
- Age ≥18 years;
- All sexes eligible
- Established diagnosis of LS performed as part of clinical practice, with a germline pathogenic/likely pathogenic variant in one of the following genes: MLH1, MSH2, MSH6, PMS2, and EpCAM
- LS subjects undergoing surveillance gastrointestinal endoscopy according to clinical practice and international guidelines.
- Subjects underwent dental and periodontal examination
Exclusion criteria
- Age < 18 years;
- Absence of sufficient periodontal clinical or radiographic data to establish a periodontal diagnosis;
- Subjects affected by systemic, autoimmune, chronic inflammatory, neurological, or severe psychiatric disorders, or by any other clinical condition that may interfere with study participation or data interpretation
- Subjects with systemic conditions known to strongly affect periodontal status (e.g. uncontrolled diabetes, autoimmune inflammatory diseases, ongoing cancer therapy) were excluded to reduce major confounding factors that could independently alter periodontal outcomes.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Case-control
Study locations
Italy · 1 center
- IRCCS San Raffaele — Milan
Identifiers
NCT: NCT07600710 · CET79-2026