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Evaluation of a Virtual Reality-based Version of the Multiple Errands Test in Alcohol Use Disorder

No phase Interventional Alcohol Use Disorder (AUD)

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Multiple Errand Test (MET), Virtual MET.
Who it may be relevant to
Registry conditions: Alcohol Use Disorder (AUD). Basic parameters: 18 years — 65 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
France
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Evaluation of a Virtual Reality-based Version of the Multiple Errands Test for the Assessment of Executive Functions in Alcohol Use Disorder

Overview

The goal of this study is to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive functions in patients with alcohol use disorder (AUD). More specifically, the project aims to: 1. evaluate if the performance in the virtual version of the test is related to the performance in the original test in patients with AUD. 2. establish whether the virtual version of the test is sensitive enough to detect patients with or without an executive function deficit. All participants will perform the original version (in a real-life supermarket) and the virtual version of the test (in a virtual reality environment). Performance in the two versions of the test will be compared. Participants will also complete a battery of neuropsychological tests and questionnaires.

Detailed description

The project aims to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive function in patients with alcohol use disorder (AUD), in comparison to the original test (MET), by:

1. establishing the ecological validity of the V-MET: a high correlation between performance on the MET and performance on the V-MET (total number of errors) in patients with TUAL and executive dysfunction. 2. establishing the sensitivity of the V-MET (to executive dysfunction): significant difference between V-MET performance in patients with an AUD and executive dysfunction versus (a) patients without executive dysfunction and (b) "healthy" volunteers

Interventions

  • Behavioral Multiple Errand Test (MET)
    The test takes place in a real supermarket. Participants must complete a list of tasks (e.g., purchasing certain items, collecting some information) while adhering to rules (e.g., not visiting the same place twice, etc).
  • Behavioral Virtual MET
    The test takes place in a virtual supermarket, developed on the C2Neuro app by C2CARE®. Participants must complete a similar list of tasks to the MET (e.g., purchasing certain items, collecting some information) and adhere to similar to rules (e.g., not visiting the same place twice, etc) .

Primary outcome measures

  • Total number of errors on the test [Time frame: Baseline]
Secondary outcome measures (4)
  • Inefficiencies on the test [Time frame: Baseline]
  • Rule breaks on the test [Time frame: Baseline]
  • Interpretation failures on the test [Time frame: Baseline]
  • Task failures on the test [Time frame: Baseline]

Eligibility criteria

Inclusion criteria

  • written consent
  • Normal or corrected vision and hearing
  • Membership or entitlement to a social security plan
  • spoken and written French
  • third party liability insurance

for patients only :

  • at least 6 criteria for AUD based on the Diagnostic and statistical manual of mental disorders
  • At the end of withdrawal: treatment with a diazepam equivalent of ≤ 20 mg/day

Exclusion criteria

  • under tutorship/ judicial protection
  • Sensory or motor impairment (impeding the use of virtual reality and/or mobility)
  • Severe neurological disorder (such as dementia or Korsakoff's syndrome)
  • Photosensitive epilepsy (contraindication for the use of virtual reality)
  • Any other condition deemed incompatible with the study, at the investigator's discretion
  • Montreal Cognitive Assessment (MoCA) score < 10 (severe cognitive impairment)
  • Breastfeeding or pregnant women
  • Familiarity with the supermarket visited during the MET test

For controls only :

  • History of alcohol use disorder
  • score ≥ 8 on the Alcohol Use Disorders Identification Test
  • Score on the Frontal Assessment Battery < 16 (or < 15 if education is below secondary level)

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Non-randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Other

Study locations

France · 2 centers
  • CH Le Vinatier — Bron
  • Hôpital de la Croix Rousse — Lyon

Identifiers

NCT: NCT07593664 · 2025-A00421-48

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗