Combination vs. Monotherapy for Stenotrophomonas Maltophilia Infections
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Bloodstream Infection, Pneumonia - Bacterial, S Maltophilia Infections. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Spain
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Combination vs. Monotherapy for Stenotrophomonas Maltophilia Infections: A Multicentre Study Using Target Trial Emulation
Overview
The goal of this multicentre observational study is to analyse the treatment strategies and the outcomes for patients with S. maltophilia infections using target trial emulation methodology. The main question it aims to answer is: • Does combined therapy achieve better results than monotherapy in treating S. maltophilia infections? Researchers will compare groups receiving monotherapy and combined therapy to see if there are differences in all-cause 30-day mortality.
Primary outcome measures
- All-cause mortality [Time frame: At 30 days]
- All-cause mortality [Time frame: At 60 days]
Secondary outcome measures (2)
- Frequency of complications [Time frame: At 60 days]
- Frequency of adverse events [Time frame: At 60 days]
Eligibility criteria
Inclusion criteria
- Adult patients
- S. maltophilia infections
- Different episodes if a new infection ocurred > 30 days since the index episode
Exclusion criteria
- isolates obtained from patients outside of hospital admission
- microbiological or clinical colonization
- hospitalizations shorter than 72 hours since the time zero
- patients who died in the first 72 hours since the time zero or who were in imminent risk of death
- polymicrobial infections
- receipt of inappropriate therapy after the time of the emulated randomization, defined as the absence of in vitro active antimicrobials or the administration of active antimicrobials for less than 48 hours
- absence of data outcomes
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Spain · 1 center
- Microbiology and Infectious Disease Department, Hospital General Universitario Gregorio Ma — Madrid
Identifiers
NCT: NCT07593547 · MICRO.HGUGM.2025-015