Intraoperative CO₂ (Carbon Dioxide)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: CO2 Fractionated Laser, Non CO2 Laser Treatment.
- Who it may be relevant to
- Registry conditions: Wound Edges. Basic parameters: 18 years — 89 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Intraoperative Fractionated CO₂ Laser Treatment of Wound Edges During Mohs Micrographic Surgery
Overview
To evaluate whether intraoperative fractionated CO₂ laser treatment of surgical wound edges improves postoperative scar appearance compared with untreated wound edges following Mohs micrographic surgery (MMS).
Detailed description
This is a randomized, split-scar clinical study. After patients undergo the MMS surgery and before the wound is closed one half of the wound edge will be treated with a CO2 laser and the other half will be untreated. The side of the would receiving the laser treatment will be determined by random assignment. The study aims to evaluate if the wound edge that is laser treated will have an improved scar appearance compared to the non-laser treated wound edge.
Interventions
- Device CO2 Fractionated Laser
intraoperative fractionated CO₂ laser treatment of surgical wound edges - Procedure Non CO2 Laser Treatment
Untreated CO2 fractionated laser wound edges
Primary outcome measures
- Improvement of postoperative scar appearance [Time frame: 3 months]
Secondary outcome measures (3)
- Scar Appearance [Time frame: 3 months]
- Physician Scar Assessments [Time frame: 3 months]
- Clinical Safety and Healing Outcomes. [Time frame: 1 week, 1 month, 3 months]
Eligibility criteria
Inclusion criteria
- Adults aged 18-89 years
- Diagnosis of cutaneous malignancy treated with MMS
- Surgical defect suitable for primary linear or flap closure with adequate length to permit split-scar design
- Ability to understand and provide informed consent
Exclusion criteria
- Pregnancy
- Inability to provide informed consent
- Non-English speaking patients
- History of abnormal wound healing (e.g., keloid disorder)
- Active infection at the surgical site
- Immunosuppression felt to significantly impair wound healing
- Use of isotretinoin within the past 6 months
- Prior radiation therapy to the surgical site
- Patients belonging to vulnerable populations including prisoners, children, or individuals unable to consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Double blind
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Baylor University Medical Center — Dallas
Publications
- Ji Q, Luo L, Ni J, Pu X, Qiu H, Wu D. Fractional CO2 Laser to Treat Surgical Scars: A System Review and Meta-Analysis on Optimal Timing. J Cosmet Dermatol. 2025 Jan;24(1):e16708. doi: 10.1111/jocd.16708. PMID 39780524
- Ozog DM, Moy RL. A randomized split-scar study of intraoperative treatment of surgical wound edges to minimize scarring. Arch Dermatol. 2011 Sep;147(9):1108-10. doi: 10.1001/archdermatol.2011.248. No abstract available. PMID 21931055
Identifiers
NCT: NCT07592468 · 026-177