Effect of Periodontal Therapy on Asprosin in Stable Angina
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning).
- Who it may be relevant to
- Registry conditions: Stable Angina Pectoris, Periodontitis. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Turkey (Türkiye)
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Effect of Non-Surgical Periodontal Therapy on Serum Asprosin in Patients With Stable Angina
Overview
This study aims to evaluate the effect of non-surgical periodontal therapy on serum asprosin levels in patients with stable angina and periodontitis. Asprosin is a novel metabolic biomarker reported to have potential protective roles in cardiovascular diseases and inflammatory processes. The study also investigates the relationship between periodontal parameters and serum asprosin levels before and after periodontal therapy.
Detailed description
Periodontitis is a chronic inflammatory disease characterized by the destruction of the tooth-supporting tissues and has been associated with increased systemic inflammation and cardiovascular diseases. Stable angina, a clinical manifestation of coronary artery disease, is closely linked to inflammatory and metabolic pathways. Increasing evidence suggests that periodontal inflammation may contribute to cardiovascular pathology through systemic dissemination of inflammatory mediators and oxidative stress mechanisms.
Asprosin is a recently identified adipokine secreted mainly from white adipose tissue and is involved in glucose metabolism, inflammatory regulation, and cardiovascular homeostasis. Previous studies have reported altered serum asprosin levels in patients with atherosclerosis, myocardial infarction, and periodontitis. However, the effect of periodontal therapy on serum asprosin levels in patients with stable angina has not yet been clinically investigated.
In this clinical study, 60 individuals will be allocated into three groups: healthy controls, periodontitis patients, and patients with stable angina and periodontitis. Non-surgical periodontal therapy will be performed in periodontitis groups, while supragingival scaling and oral hygiene instructions will be provided for controls. Clinical periodontal parameters and serum asprosin levels will be evaluated at baseline and at 3-month follow-up using ELISA analysis.
The study aims to determine whether periodontal therapy may influence serum asprosin levels and to evaluate the possible relationship between periodontal inflammation and metabolic-inflammatory pathways in cardiovascular disease. To the best of our knowledge, this is the first clinical study evaluating the effect of periodontal therapy on serum asprosin levels in patients with stable angina.
Interventions
- Procedure Non-surgical periodontal therapy (scaling and root planing)
Non-surgical periodontal therapy will include full-mouth scaling and root planing performed using hand instruments and/or ultrasonic devices to remove supra- and subgingival plaque and calculus. - Procedure Non-surgical periodontal therapy (Professional dental cleaning)
Supragingival calculus and plaque removal with standardized oral hygiene instruction.
Primary outcome measures
- Change in serum asprosin levels after non-surgical periodontal therapy [Time frame: Baseline and 3 months]
Eligibility criteria
Inclusion criteria
- Willingness to participate in the study and provide written informed consent
- Age 18 years or older
- No periodontal treatment within the past 6 months
- No use of local or systemic antibiotics within the past 3 months
Exclusion criteria
- Unwillingness to participate in the study or to provide informed consent
- Age under 18 years
- Use of local or systemic antibiotics for the treatment of widespread infection within the past 3 months
- Receipt of periodontal treatment within the past 6 months
- Pregnancy or lactation (for female participants)
- History of acute myocardial infarction within the past 6 months
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Turkey (Türkiye) · 1 center
- Ondokuz Mayis University — Samsun
Publications
- Gul SNS, Birdal O, Laloglu E. Serum asprosin levels are increased in patients with periodontitis and ST-segment elevation myocardial infarction and correlated with periodontal parameters: A case-control study. J Periodontal Res. 2024 Apr;59(2):259-266. doi: 10.1111/jre.13210. Epub 2023 Nov 20. PMID 37984462
Identifiers
NCT: NCT07591844 · OMU-306 · 5673