SNRK & Vascular Endothelial Aging
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: serum tests and carotid ultrasound test.
- Who it may be relevant to
- Registry conditions: Vascular Aging. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Association Between SNRK and Vascular Endothelial Aging
Overview
Cardiovascular diseases pose a serious threat to public health, and their prevalence is on the rise year by year. Vascular aging is an independent risk factor for cardiovascular diseases, and endothelial cell senescence is an early event in vascular aging. Its occurrence can lead to endothelium-dependent vasodilation dysfunction, reduced vascular permeability, and the release of the senescence-associated secretory phenotype (SASP). These vascular pathological changes further damage the vascular media, leading to vascular remodeling and reduced compliance, accelerating the progression of atherosclerosis, and ultimately resulting in cardiovascular diseases such as coronary heart disease and hypertension. Recent research of the investigators has revealed that SNRK, a new member of the AMPK family of cellular energy sensors, plays a key regulatory role in vascular development. Based on this finding, the investigators propose the scientific hypothesis that SNRK responds to both physiological and pathological aging stimuli through differential mechanisms and regulates the process of endothelial cell senescence. In this study, the investigators will explore the correlation between SNRKAS and carotid vascular structure and endothelial function by measuring the levels of the SNRK upstream lncRNA (SNRKAS) in participants' peripheral blood, in conjunction with carotid ultrasound examinations. The findings will provide a solid scientific basis for elucidating new mechanisms underlying the onset and progression of vascular aging and for identifying novel therapeutic targets.
Interventions
- Diagnostic test serum tests and carotid ultrasound test
1. 10 mL of venous blood was drawn from each participant to measure blood lipids and serum levels of SNRKAS (using RT-qPCR), and to perform transcriptomic analysis. 2. Carotid ultrasound was used to measure circumferential strain and pulse wave velocity in both carotid arteries to assess the degree of arterial stiffness.
Primary outcome measures
- Serum levels of SNRKAS detected by RT-PCR [Time frame: At enrollment]
- Degree of bilateral carotid artery stenosis detected by Doppler ultrasound [Time frame: At enrollment]
- Pulse wave velocity in both carotid arteries detected by Doppler ultrasound [Time frame: At enrollment]
Secondary outcome measures (1)
- Blood lipids levels detected by automated biochemical analyzer (LABOSPECT 008, Hitachi) [Time frame: At enrollment]
Eligibility criteria
Inclusion criteria
- Aged 18-80 years, with the capacity to make decisions independently or represented by an authorized legal guardian;
- Able to provide complete personal information, medical history, and lifestyle history (e.g., smoking and alcohol consumption history);
- No history of severe cardiovascular disease, and deemed eligible for inclusion by a physician.
Exclusion criteria
- Women who are pregnant or may become pregnant;
- Patients with a history of neurological disorders, tumors, severe cardiovascular or pulmonary disease, liver failure, kidney failure, or blood disorders;
- Patients who have undergone carotid stenting, carotid endarterectomy, or other similar procedures, or who have unilateral carotid artery occlusion due to any cause;
- Patients who have participated in another clinical trial within the past 4 weeks;
- Individuals deemed unsuitable for this clinical trial by the investigators.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Tianjin Medical University General Hospital — Tianjin
Identifiers
NCT: NCT07591337 · IRB2026-YX-172-01