Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Optical Coherence Tomography assessment.
- Who it may be relevant to
- Registry conditions: Stable Coronary Artery Disease, Acute Coronary Syndromes, Critical Limb Ischemia, Intermittent Claudication. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Local And Systemic Macrophage Activation in Coronary and Peripheral Artery Disease: the LAST-COP Study
Overview
Numerous clinical studies have highlighted the role of macrophages in the destabilization of coronary lesions; however, there is limited literature on the relationship between circulating monocytes and intraplaque macrophages. This study aims to evaluate and compare the presence of macrophages and their subsequent activation within coronary and peripheral atherosclerotic lesions, and to correlate these findings with the distribution of circulating monocyte subpopulations.
Interventions
- Diagnostic test Optical Coherence Tomography assessment
assessment of the number of infiltrating macrophages
Primary outcome measures
- presence of macrophages and their activation within coronary and peripheral atherosclerotic lesions [Time frame: From enrollment to hospital discharge following peripheral angiography/coronary angiography]
Eligibility criteria
Inclusion criteria
- Patients with chronic coronary artery disease;
- Patients with no-ST elevation acute coronary syndrome;
- Patients with chronic claudication (Rutherford II-III)
- Patients with critical limb ischemia (Rutherford IV-V).
Exclusion criteria
- Severe renal dysfunction
- Severe valve disease
- Advanced heart failure
- Advanced liver disease
- Chronic inflammatory or autoimmune disease
- Use of antinflammatory drugs
- Acute infection
- Recent surgical procedures
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Diagnostic
Study locations
Italy · 1 center
- Maria Cecilia Hospital — Cotignola
Identifiers
NCT: NCT07588295 · LAST COP