Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: continuous renal replacement therapy.
- Who it may be relevant to
- Registry conditions: AKI - Acute Kidney Injury, Critical Illness. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
CIILOS - Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay
Overview
This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive care unit (ICU) length of stay (LOS).
Detailed description
This large national cohort study, including over 500,000 patients, aims to evaluate the association between time to initiation of continuous renal replacement therapy (CRRT) and intensive care unit (ICU) length of stay (LOS).
The investigators hypothesize that earlier start of CRRT is associated with shorter length of stay among critically ill patients.
CRRT is seen as a costly intervention, and after studies failing to demonstrate a mortality benefit from earlier initiation, the trend is to push, or postpone the start of CRRT. In Sweden the additional cost of CRRT amounts to around 5000 SEK, approximately 500 dollars/euros per 24 hours. However, the 24-hour cost of staying in the ICU is around 58000 SEK or 5800 dollars/euros.
Interventions
- Device continuous renal replacement therapy
We are evaluting early vs late initiation of CRRT
Primary outcome measures
- Intensive care unit (ICU) length of stay (LOS) measured in hours [Time frame: ICU LOS during the study period, from admission to discharge, average 168 hours (one week)]
Secondary outcome measures (2)
- Mortality [Time frame: ONE-YEAR Mortality post admission]
- Mechanical ventilation [Time frame: Time on mechanical ventilation during the study period, average one week, but up to ICU discharge]
Eligibility criteria
Inclusion criteria
- Patients with critical illness
- Admitted to Swedish ICUs from 2010-2023
- Adult (18 years or older)
Exclusion criteria
\*Patients under 18 years of age
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07586059 · CIILOS