Postoperative Pain and Substance P Levels After Bioceramic vs Calcium Hydroxide Intracanal Medicaments in Symptomatic Apical Periodontitis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Calcium Hydroxide (Ca(OH)2), Bioceramic Intracanal Medicament.
- Who it may be relevant to
- Registry conditions: Symptomatic Apical Periodontitis. Basic parameters: 18 years — 45 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Clinical Evaluation of the Postoperative Pain and Substance P Levels Following the Use of Bioceramic Verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular Molars With Symptomatic Apical Periodontitis
Overview
Clinical Evaluation of the Postoperative Pain and Substance P levels Following the use of Bioceramic verses Calcium Hydroxide Intracanal Medicaments in Permanent Mandibular molars with Symptomatic Apical Periodontitis
Detailed description
This study aims to evaluate postoperative pain levels and Substance P expression following the use of two different intracanal medicaments: bioceramic materials and calcium hydroxide in permanent mandibular molars diagnosed with symptomatic apical periodontitis.
A total of 28 patients will be included in this study and randomly allocated into two equal groups (n=14 each). Group I will receive calcium hydroxide (Ca(OH)₂) as an intracanal medicament, while Group II will receive a bioceramic intracanal medicament.
Standardized endodontic procedures will be performed for all participants. Postoperative pain will be assessed using a visual analog scale (VAS) at different time intervals following treatment.
In addition, samples will be collected to evaluate Substance P levels as a biochemical marker associated with pain and inflammation.
The comparison between the two groups will help determine the effectiveness of each intracanal medicament in reducing postoperative pain and inflammatory response. The results of this study may contribute to improving clinical decision-making in endodontic therapy.
Interventions
- Drug Calcium Hydroxide (Ca(OH)2)
Calcium hydroxide will be used as an intracanal medicament during root canal treatment in Permanent Mandibular molars with Symptomatic Apical Periodontitis - Drug Bioceramic Intracanal Medicament
Bioceramic material will be used as an intracanal medicament during root canal treatment in Permanent Mandibular molars with Symptomatic Apical Periodontitis
Primary outcome measures
- Assessment of postoperative pain levels [Time frame: one week]
Secondary outcome measures (1)
- neurogenic biomarker Substance P Level [Time frame: one week after the pulp Extirpation]
Eligibility criteria
Inclusion criteria
- \- Patients aged 18-45 years with no sex predilection
- Medically free Patients with no systemic conditions that can affect post operative pain response.
- Patients should not be taking any pain medications 24 hours before intervention
- Positive patients' acceptance for participating in the study
- Patient able to sign informed consent
- Permanent mandibular molars diagnosis with Symptomatic Apical Periodontitis
- Permanent molars without any anatomical variations or severe curvatures
Exclusion criteria
- \- Medically compromised patients
- Patients who have received antibiotic therapy within the last 2 weeks.
- Pregnant or lactating women.
- Patients with known allergy to any of the irrigants used.
- Patients with swelling or acute peri-apical abscess or fistulous tract.
- Teeth that have:
- Wide or open apex .
- Vital pulp tissue .
- Periodontally affected with grade 2or 3 mobility.
- Non restorable teeth .
- Abnormal anatomy and calcified canals .
- Pervious root canal treatment.
- severe curved canal
- Buccolingual and mesiodistal radiographs were taken to evaluate the root canal anatomy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT07585721 · FUE.REC(24)/2-2026